“…The primary goal of tissue engineering is the augmentation of bone deficiencies throughout the body, particularly in the craniofacial region ( Lopez et al, 2021 , Mossaad et al, 2021 ). Bone regeneration replacement materials must be biocompatible, biodegradable, easy to apply, effective for bone repair, and highly adaptable to bone defects ( Helal et al, 2016 , Veljanovski et al, 2021 , Wang et al, 2002 ). Various scaffold types and natural or synthetic materials, such as metals, ceramics, and polymers, have been used to stimulate and enhance bone regeneration ( Kim et al, 2021 , Lim et al, 2021 ).…”