Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

Neguț, Irina; Ristoscu, Carmen; Tozar, Tatiana; Dinu, Mihaela; Parau, Anca Constantina; Grumezescu, Valentina; Popa, Marcela; Stan, Miruna Silvia; Măruţescu, Luminiţa; Mihailescu, Ion N.; Chifiriuc, Mariana Carmen

doi:10.3390/pharmaceutics14061175

Cited by 9 publications

(11 citation statements)

References 61 publications

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“…The high absorbance, between 200-400 nm, makes it a natural choice for sunscreen and protection treatments, alongside TiO 2 [11][12][13]. As a semiconductor, due to its transparent coccus aureus, Bacillus cereus, Bacillus subtilis, and Enterococcus faecalis, which are responsible for many implants' failure [75,76], skin infections [77], or foodborne illnesses [78], and a fungal strain Candida albicans, responsible for oral and vaginal candidiasis [79][80][81].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

et al. 2022

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Zinc oxide (ZnO) nanomaterials are used in various health-related applications, from antimicrobial textiles to wound dressing composites and from sunscreens to antimicrobial packaging. Purity, surface defects, size, and morphology of the nanoparticles are the main factors that influence the antimicrobial properties. In this study, we are comparing the properties of the ZnO nanoparticles obtained by solvolysis using a series of alcohols: primary from methanol to 1-hexanol, secondary (2-propanol and 2-butanol), and tertiary (tert-butanol). While the synthesis of ZnO nanoparticles is successfully accomplished in all primary alcohols, the use of secondary or tertiary alcohols does not lead to ZnO as final product, underlining the importance of the used solvent. The shape of the obtained nanoparticles depends on the alcohol used, from quasi-spherical to rods, and consequently, different properties are reported, including photocatalytic and antimicrobial activities. In the photocatalytic study, the ZnO obtained in 1-butanol exhibited the best performance against methylene blue (MB) dye solution, attaining a degradation efficiency of 98.24%. The comparative study among a series of usual model dyes revealed that triarylmethane dyes are less susceptible to photo-degradation. The obtained ZnO nanoparticles present a strong antimicrobial activity on a broad range of microorganisms (bacterial and fungal strains), the size and shape being the important factors. This permits further tailoring for use in medical applications.

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Section: Introductionmentioning

confidence: 99%

Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

et al. 2022

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“…As mentioned in the previous sections, when BGs are used to coat metallic implants, a hydroxyapatite-like phase can form at the site where the implant meets the host tissue, aiding in the implant's better integration [74]. BGs of excellent bioactivity have been used by our group onto less biocompatible or bioinert materials (such as titanium or steel) in the form of coatings [75][76][77][78] [75][76][77][78].…”

Section: Bg Thin Filmsmentioning

confidence: 99%

Bioactive Glasses for Soft and Hard Tissue Healing Applications—A Short Review

Neguț

Ristoscu

2023

Applied Sciences

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Bioactive glasses have developed into a variety of items that are used in order to treat a wide range of medical problems. Apart from being mostly applied in the healing processes of hard tissues, bioactive glasses are becoming very popular materials in soft tissues healing. Bioactive glasses have exhibited the ability to accelerate skin regeneration by enhancing angiogenesis and collagen deposition in the proliferation stage, as well as positive effects on all the other important stages of wound healing. They can adhere to hard tissues such as bone and aid in the regeneration of those tissues by forming a calcium–phosphate-like layer on their surfaces. The formation of this apatite layer results in a linkage between the hard tissue and the glass, which further leads to bone healing. This short review summarizes the dynamic process of wound healing along with the basic concepts of bioactive glasses applied in this domain. We aimed to explore constructs which aid different phases of wound healing. Moreover, several research studies dedicated to bioactive glass thin films are briefly discussed.

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“…Specific to this technique, the organic material is dissolved in a volatile solvent before being frozen at N 2 temperature. The photochemical degradation of the organic substance can be decelerated or even stopped by hitting the frozen target with a pulsed laser beam whose energy is absorbed by the solvent and turned into thermal energy [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium Phosphates–Chitosan Composite Layers Obtained by Combining Radio-Frequency Magnetron Sputtering and Matrix-Assisted Pulsed Laser Evaporation Techniques

et al. 2022

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In this work, we report the synthesis of calcium phosphate–chitosan composite layers. Calcium phosphate layers were deposited on titanium substrates by radio-frequency magnetron sputtering technique by varying the substrate temperature from room temperature (25 °C) up to 100 and 300 °C. Further, chitosan was deposited by matrix-assisted pulsed laser evaporation technique on the calcium phosphate layers. The temperature at the substrate during the deposition process of calcium phosphate layers plays an important role in the embedding of chitosan, as scanning electron microscopy analysis showed. The degree of chitosan incorporation into the calcium phosphate layers significantly influence the physico-chemical properties and the adherence strength of the resulted layers to the substrates. For example, the decreases of Ca/P ratio at the addition of chitosan suggests that a calcium deficient hydroxyapatite structure is formed when the CaP layers are generated on Ti substrates kept at room temperature during the deposition process. The Fourier transform infrared spectroscopy analysis of the samples suggest that the PO43−/CO32− substitution is possible. The X-ray diffraction spectra indicated that the crystalline structure of the calcium phosphate layers obtained at the 300 °C substrate temperature is disturbed by the addition of chitosan. The adherence strength of the composite layers to the titanium substrates is diminished after the chitosan deposition. However, no complete exfoliation of the layers was observed.

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Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

Cited by 9 publications

References 61 publications

Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

Influence of the Alcohols on the ZnO Synthesis and Its Properties: The Photocatalytic and Antimicrobial Activities

Bioactive Glasses for Soft and Hard Tissue Healing Applications—A Short Review

Calcium Phosphates–Chitosan Composite Layers Obtained by Combining Radio-Frequency Magnetron Sputtering and Matrix-Assisted Pulsed Laser Evaporation Techniques

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