Implantable cardiac pacemakers

Dubrovskii, I. A.; Grigorov, S. S.; Bezzubchikov, V. A.; Васильев, А. Ю.

doi:10.1007/bf00556275

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Successful outcomes will not only contribute to our knowledge of the (patho)physiological function of brain and heart systems, but also greatly facilitate the development of treatment methodologies for neurological disorders and cardiovascular diseases. In this context, a significant research effort focuses on developing advanced electrical and optical interfaces to interact with various parts of these organs. − For example, microelectrodes are one of the most widely applied tools to record action potentials and local field potentials with high temporal resolution from the brain and heart to reflect their physiological states and monitoring health status. − Direct microelectrode-based electrical stimulations, such as cardiac pacing − and deep brain stimulation, , are clinically used to treat arrhythmias and Parkinson’s disease by triggering an action potential with an external current and changing the membrane potential. Despite the tremendous impact of microelectrode-based electrical recording and stimulation approaches on fundamental research and translational development, they have limited spatial resolution, which is crucial to differentiate cell types, shapes, and understand the complicated network connections.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress on Transparent Microelectrode-Based Soft Bioelectronic Devices for Neuroscience and Cardiac Research

2023

ACS Appl. Bio Mater.

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Transparent microelectrodes have emerged as promising tools to combine electrical and optical sensing and modulation modalities in many areas of biological and biomedical research. Compared to conventional opaque microelectrodes, they offer a number of specific advantages that can enable advances in functionality and performance. In addition to optical transparency, the mechanical softness feature is desired to minimize foreign body responses, increase biocompatibility, and avoid loss of functionality. In this review, we present recent research from the past several years on transparent microelectrode-based soft bioelectronic devices with an emphasis on their material properties and advanced device designs, as well as multimodal application scenarios for neuroscience and cardiology. First, we introduce material candidates with proper electrical, optical, and mechanical properties for soft transparent microelectrodes. We then discuss examples of soft transparent microelectrode arrays tailored to combine electrical recording and/or stimulation with optical imaging and/or optogenetic modulation of the brain and the heart. Next, we summarize the most recent progress on soft opto-electric devices integrating transparent microelectrodes with microscale light-emitting diodes and/or photodetectors into single and hybrid microsystems as powerful tools to explore the brain and heart functions. A brief overview of possible future directions of soft transparent microelectrode-based biointerfaces is provided to conclude the review.

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Section: Introductionmentioning

confidence: 99%

Recent Progress on Transparent Microelectrode-Based Soft Bioelectronic Devices for Neuroscience and Cardiac Research

2023

ACS Appl. Bio Mater.

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“…Since Luigi Galvani first revealed the electrical activities of neurons and muscle cells by probing tissues with metal wires in the 18th century, scientists have made substantial progress in understanding the physiological and pathophysiological functions of nervous and cardiac systems by developing bioelectronics to interface with neurons and cardiomyocytes at ever-increasing spatiotemporal resolution and scale. Examples include, but are not limited to, the pace maker, patch-clamp, , Michigan probe, Utah array, sharp electrodes, − flexible electrode array, − stretchable electrode array, and complementary metal-oxide-semiconductor (CMOS) driven high-density electrode array. − …”

Section: Introductionmentioning

confidence: 99%

“…Since Luigi Galvani first revealed the electrical activities of neurons and muscle cells by probing tissues with metal wires 10 in the 18th century, scientists have made substantial progress in understanding the physiological and pathophysiological functions of nervous and cardiac systems by developing bioelectronics to interface with neurons and cardiomyocytes at ever-increasing spatiotemporal resolution and scale. Examples include, but are not limited to, the pace maker, 11 patch-clamp, 12,13 Michigan probe, 14 Utah array, 15 sharp electrodes, 16−19 flexible electrode array, 20−22 stretchable electrode array, 23 and complementary metal-oxide-semiconductor (CMOS) driven high-density electrode array. 24−26 Despite this progress, building implantable bioelectronics, capable of simultaneously probing the statistically significant number of cells across the entire 3D tissue in a chronically stable manner with cell-type specificity, remains a challenge, which requires synergistic development in materials science, electrical engineering, mechanical engineering, and genetic engineering.…”

Section: Introductionmentioning

confidence: 99%

From Lithographically Patternable to Genetically Patternable Electronic Materials for Miniaturized, Scalable, and Soft Implantable Bioelectronics to Interface with Nervous and Cardiac Systems

Liu

Zhao

Liu

2020

ACS Appl. Electron. Mater.

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Soft implantable bioelectronics, capable of maintaining an intimate, chronically stable tissue interface to provide single-cell spatial resolution, millisecond temporal resolution, and cell-type-specific interrogation and intervention, are important to biological research and clinical application. Despite remarkable advancements in recent years, the establishment of miniaturized, scalable, and soft bioelectronic interfaces to a large number of cells three-dimensionally (3D) distributed across cardiac and neural tissues in freely behaving animals and human subjects remains a challenge. In this Review, we discuss recent progress in studies and designs of lithographically and/or genetically patternable electronic materials to address these questions. First, we summarize the development of lithographically patternable electronic materials with proper electrical and mechanical properties, biocompatibility, and long-term stability for implantable bioelectronics. Then, we discuss examples of miniaturized, scalable, and soft implantable bioelectronics for brain and heart interfaces. Next, we introduce the most recent progress on the genetically targeted assembly and patterning of electrically functional polymeric materials on the neurons in intact 3D brains through the convergence of synthetic biology and polymer chemistry. Finally, the perspective of future development of implantable bioelectronics through the convergence of materials science, electrical engineering, and synthetic biology is discussed.

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Implantable cardiac pacemakers

Cited by 2 publications

References 6 publications

Recent Progress on Transparent Microelectrode-Based Soft Bioelectronic Devices for Neuroscience and Cardiac Research

Recent Progress on Transparent Microelectrode-Based Soft Bioelectronic Devices for Neuroscience and Cardiac Research

From Lithographically Patternable to Genetically Patternable Electronic Materials for Miniaturized, Scalable, and Soft Implantable Bioelectronics to Interface with Nervous and Cardiac Systems

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