Implantable cardioverter–defibrillator infection due to Corynebacterium xerosis

Martí, Juan; Antón, Enrique; Idoate, A.

doi:10.1016/j.ijcard.2007.04.105

International Journal of Cardiology

2008

DOI: 10.1016/j.ijcard.2007.04.105

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Implantable cardioverter–defibrillator infection due to Corynebacterium xerosis

Juan Martí

Enrique Antón

A. Idoate

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“…Corynebacterium xerosis has been found to cause problems in people who are immunocompromised and was isolated from people with endocarditis. [1][2][3][4] Studies have demonstrated the presence of C. xerosis in wounds, 5,6 in breast abscesses, 7 and prosthetic devices. 8,9 Further, this bacterium has affected people who have spent long periods in hospitals and those with conjunctivitis 8,9 or septicemia.…”

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Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Soultanov

Kraeva

2020

Natural Product Communications

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Traditionally, preservatives have been used in cosmetic products to minimize bacterial contamination. Some opportunistic Corynebacterium spp. have become resistant to these preservatives and other alternatives are required. A potential candidate is Conifer Green Needle Complex (CGNC), a pharmaceutical-grade complex substance from the green verdure of Pinus sylvestris and Picea abies with antibacterial, antimycotic, and antitrichomonal activity. The susceptibility of Corynebacterium xerosis and Corynebacterium flavescens to CGNC (3.5, 7, 15, 30, 60, 125, 250, and 500 mg/mL) was evaluated using broth dilution and agar methods. The antibacterial effect of CGNC was also evaluated after exposure for 30 minutes and 1, 3, and 24 hours at concentrations of 0, 3.5, 7, 30, 125, and 500 mg/mL. Corynebacteria xerosis was inhibited when exposed to low levels of CGNC (1560 mg/mL), whereas an antibacterial effect on C. flavescens was observed at slightly higher levels (60 and 125 mg/mL). CGNC also inhibited the growth of C. xerosis and C. flavescens at various incubation time points. The most prominent effect was observed after 24 hours where all growth was inhibited at all concentrations. However, CGNC inhibited or decreased the growth of Corynebacterium spp. even at lower exposure times. The results obtained in this study demonstrated that CGNC is an effective bactericidal agent against C. xerosis and C. flavescens isolated from clinical samples and may have potential as an alternative to preservatives currently used in cosmetic products.

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Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Soultanov

Kraeva

2020

Natural Product Communications

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Outcome of Corynebacterial Bloodstream Infection in Patients With Cardiac Implantable Electronic Devices: A Brief Report and Systematic Review

Chesdachai,

Baddour,

Sohail

et al. 2024

Open Forum Infectious Diseases

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Implantable cardioverter–defibrillator infection due to Corynebacterium xerosis

Cited by 2 publications

References 5 publications

Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Antibacterial Activity of Conifer Green Needle Complex Against Corynebacteria

Outcome of Corynebacterial Bloodstream Infection in Patients With Cardiac Implantable Electronic Devices: A Brief Report and Systematic Review

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