Implantable drug delivery devices

Chappel, Eric

doi:10.1016/b978-0-12-819838-4.00001-8

Cited by 19 publications

(15 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the pharmacological concentration of sBV should be considered in clinical trials, if it is possible. According to the previous literature, the effects of drugs and poisons were determined to be closely related to the concentration applied [ 54 , 55 , 56 ]. Thus, we can suggest that sBV exhibits both pharmacological effects and toxic effects depending on its concentration.…”

Section: Discussionmentioning

confidence: 99%

Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells

Ryu

Park

et al. 2022

Genes

View full text Add to dashboard Cite

Sweet bee venom (sBV) contains various pharmacologically active components of bee venom (BV), but it is modified via the removal of the harmful substances found in BV. Thus, sBV has been used for pain relief in Oriental medicine but has only recently been applied for the treatment of various diseases. In this study, we examined the pharmacological effects and immunomodulatory functions of sBV in THP-1 monocytic leukemia cells. Growth inhibition and cell death were observed according to the concentration of sBV. However, the rapid collapse of cell cycle distribution was shown at 20 μg/mL sBV treatment, indicating that sBV led to cell death or acute cell rupture according to concentration. sBV administration activated Caspase-9, PARP1, RIPK1, and RIPK3, suggesting that the pharmacological actions of sBV were associated with induction of apoptosis and necroptosis. On the other hand, sBV or LPS administration increased cytokine expression, including IL-1β, and showed synergistic cell death in combinatory treatment conditions. Moreover, combinatory administration of sBV and LPS induced severe damage or death during egg development. This result implies that sBV exhibits both pharmacological and toxic effects depending on its concentration. Therefore, sBV might be a promising therapeutic approach, but optimal concentration should be considered before treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells

Ryu

Park

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

“…185 To meet these needs, recent work focuses on the development of miniaturized, microfluidic neural probes 186,187 and implantable drug chambers. 188 When combined with wirelessly programmable control modules, such systems have strong potential not only as neural interfaces but also as advanced treatment protocols for hormonal imbalances, diabetic conditions, cancers, and others. 189,190 A complementary use of related technologies focuses on the collection of brain interstitial fluid (ISF) for neurochemical sampling and analysis to assess neurological function.…”

Section: Pharmacological Techniquesmentioning

confidence: 99%

“…Platforms capable of targeting subpopulations of neural circuits within sub cubic millimeter volumes are of interest for spatially precise pharmacological delivery, using small, controlled dosing strategies . To meet these needs, recent work focuses on the development of miniaturized, microfluidic neural probes , and implantable drug chambers . When combined with wirelessly programmable control modules, such systems have strong potential not only as neural interfaces but also as advanced treatment protocols for hormonal imbalances, diabetic conditions, cancers, and others. , …”

Section: Materials For Neural Interfacesmentioning

confidence: 99%

Materials Chemistry of Neural Interface Technologies and Recent Advances in Three-Dimensional Systems

et al. 2021

View full text Add to dashboard Cite

Advances in materials chemistry and engineering serve as the basis for multifunctional neural interfaces that span length scales from individual neurons to neural networks, neural tissues, and complete neural systems. Such technologies exploit electrical, electrochemical, optical, and/or pharmacological modalities in sensing and neuromodulation for fundamental studies in neuroscience research, with additional potential to serve as routes for monitoring and treating neurodegenerative diseases and for rehabilitating patients. This review summarizes the essential role of chemistry in this field of research, with an emphasis on recently published results and developing trends. The focus is on enabling materials in diverse device constructs, including their latest utilization in 3D bioelectronic frameworks formed by 3D printing, self-folding, and mechanically guided assembly. A concluding section highlights key challenges and future directions.

show abstract

“…Implantable drug delivery systems are capable of providing sustained drug delivery over prolonged periods of time [ 1 , 2 , 3 , 4 , 5 , 6 ]. The interest in this type of system has been experiencing an increase over recent years due to its potential advantages over conventional drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Radiolabeled Risperidone microSPECT/CT Imaging for Intranasal Implant Studies Development

et al. 2023

View full text Add to dashboard Cite

The use of intranasal implantable drug delivery systems has many potential advantages for the treatment of different diseases, as they can provide sustained drug delivery, improving patient compliance. We describe a novel proof-of-concept methodological study using intranasal implants with radiolabeled risperidone (RISP) as a model molecule. This novel approach could provide very valuable data for the design and optimization of intranasal implants for sustained drug delivery. RISP was radiolabeled with 125I by solid supported direct halogen electrophilic substitution and added to a poly(lactide-co-glycolide) (PLGA; 75/25 D,L-Lactide/glycolide ratio) solution that was casted on top of 3D-printed silicone molds adapted for intranasal administration to laboratory animals. Implants were intranasally administered to rats, and radiolabeled RISP release followed for 4 weeks by in vivo non-invasive quantitative microSPECT/CT imaging. Percentage release data were compared with in vitro ones using radiolabeled implants containing either 125I-RISP or [125I]INa and also by HPLC measurement of drug release. Implants remained in the nasal cavity for up to a month and were slowly and steadily dissolved. All methods showed a fast release of the lipophilic drug in the first days with a steadier increase to reach a plateau after approximately 5 days. The release of [125I]I− took place at a much slower rate. We herein demonstrate the feasibility of this experimental approach to obtain high-resolution, non-invasive quantitative images of the release of the radiolabeled drug, providing valuable information for improved pharmaceutical development of intranasal implants.

show abstract

Implantable drug delivery devices

Cited by 19 publications

References 87 publications

Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells

Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells

Materials Chemistry of Neural Interface Technologies and Recent Advances in Three-Dimensional Systems

Radiolabeled Risperidone microSPECT/CT Imaging for Intranasal Implant Studies Development

Contact Info

Product

Resources

About