Implantable electrical left ventricular assist systems: Bridge to transplantation and future

Portner, Peer M.; Oyer, Philip E.; Pennington, D. Glenn; Baumgartner, William A.; Griffith, Bartley P.; Frist, William R.; Magilligan, Donald J.; Noon, George P.; Ramasamy, N.; Miller, Phillip J.; Jassawalla, Jal S

doi:10.1016/0003-4975(89)90256-7

Cited by 203 publications

(54 citation statements)

References 20 publications

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“…The pump moves blood from the LV to aortic arch where it flows normally through the patient's arterial system. Short-term use of these devices in patients awaiting transplantation can maintain hemodynamics, improve vital organ function and exercise tolerance, allow patients to be discharged from the hospital, and provides them with a reasonable quality of life and a relatively low incidence of major adverse events (8)(9)(10)(11)(12)(13)(14)(15). Table 1 is showing a summary of some types of ventricular assist device.…”

Section: Ventricular Assist Devicesmentioning

confidence: 99%

Cardiac Compression Devices: Alternative Technology and Innovative Concept

Daliri

Yadollahi

Jadbabaei

2017

Multidiscip Cardio Annal

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Heart failure is a leading cause of death around the world. Heart transplantation is the only reliable therapy for improving functional capacity, quality of life, life expectancy, and limiting the options for heart failure patients. In fact, a large number of patients with severe heart failure in need of heart transplantation are unable to receive therapy with up to 30% mortality before a heart is donated. In recent decades, cardiac replacement and assisting therapies have presented promising outcomes to treat these end-stage patients as alternative solutions. These devices are capable of providing temporary to permanent, partial or full assistance. Such devices can be divided into two categories based on location and mechanism of augmentation: 1) devices exposed directly to blood including ventricular assistive devices (VADs) and total artificial hearts (TAHs) and 2) devices that augment cardiac output through compression of ventricles or another part of circulatory system with no direct contact to blood such as extra-cardiac compression devices (ECCDs). In recent years, novel ECCDs which compress tissue and muscles to indirectly assist blood pumping have been developed to circumscribe problems associated with blood-contacting devices and the risks involved with piercing arterial and ventricular walls. Not only do ECCDs aim to reduce risks from the patient and surgeon perspective, the complexity of engineering an intra-corporeal extra-cardiac device is also reduced.

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Section: Ventricular Assist Devicesmentioning

confidence: 99%

Cardiac Compression Devices: Alternative Technology and Innovative Concept

Daliri

Yadollahi

Jadbabaei

2017

Multidiscip Cardio Annal

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“…The NIH-sponsored programs for long-term support bore fruit in 1984 with successful deployment of the electric, pulsatile Novacor LVAD as a BTT. 8 That same year the Centers for Medicare and Medicaid Services codified distinct strategies for mechanical support to guide device development and regulatory approval (Table 1). By the mid-1990s, FDA had approved multiple pulsatile platforms allowing patients to recover from postcardiotomy shock or bridge to cardiac transplant.…”

Section: History Of Mechanical Circulationmentioning

confidence: 99%

“…By the mid-1990s, FDA had approved multiple pulsatile platforms allowing patients to recover from postcardiotomy shock or bridge to cardiac transplant. 8 The expansion of durable LVAD options for patients with advanced heart failure came just as the significant shortage of donor hearts was becoming apparent. The advanced heart failure epidemic in the United States has been estimated to include 100 000 to 250 000 patients with refractory New York Heart Association (NYHA) class IIIB or IV symptoms.…”

Section: History Of Mechanical Circulationmentioning

confidence: 99%

Mechanical Circulatory Support for Advanced Heart Failure

2012

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“…Research had demonstrated that LVAD technology could provide a relative survival benefit of approximately 30% for selected patients awaiting heart transplantation. 77,78 Following improvements in technology and the pivotal REMATCH trial which showed a 48% relative reduction in death for patients with Class IV HF and left ventricular systolic dysfunction who were randomized to the HeartMate VE pulsatile-flow LVAD compared with medical therapy, 79 the FDA in 2003 approved a pulsatile-flow LVAD for "destination" therapy. Over the remainder of the decade, pulsatile-flow LVAD technology improved with resultant reductions in percutaneous lead breaks and serious mechanical failures.…”

Section: Ventricular Assist Devicesmentioning

confidence: 99%

Most Important Outcomes Research Papers on Device Therapies for Cardiomyopathies

Gupta¹,

Dharmarajan²,

Dreyer³

et al. 2013

Circ: Cardiovascular Quality and Outcomes

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The following articles are being highlighted as part of the Circulation: Cardiovascular Quality and Outcomes Topic Review series. This series will summarize the most important manuscripts, as selected by the Editor that have published in the Circulation portfolio. The objective of this new series is to provide our readership with a timely, comprehensive selection of important papers that are relevant to the quality and outcomes, and general cardiology audience. The studies included in this article represent the most significant research related to device therapies for cardiomyopathies and its common presentation of heart failure and sudden cardiac death. (Circ Cardiovasc Qual Outcomes. 2013;6:e36-e47.)

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Implantable electrical left ventricular assist systems: Bridge to transplantation and future

Cited by 203 publications

References 20 publications

Cardiac Compression Devices: Alternative Technology and Innovative Concept

Cardiac Compression Devices: Alternative Technology and Innovative Concept

Mechanical Circulatory Support for Advanced Heart Failure

Most Important Outcomes Research Papers on Device Therapies for Cardiomyopathies

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