Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Abstract

A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.

A Wireless, Regeneratable Cocaine Sensing Scheme Enabled by Allosteric Regulation of pH Sensitive Aptamers

“…Beyond the sensing capability, magnetic resonance coupling serves as a simple, straightforward, and competing technique for powering wireless bioelectronics due to the resistance to environmental interference. ,− Additionally, separating the energy harvester from the PdNp-functionalized interface matches the design of the modularized sensor system. The “two-part” design provides opportunities for building biointegrated electronics with advanced functions and improved stability in performance.…”

Microneedle Sensors for Multiplex Applications: Toward Advanced Biomedical and Environmental Analysis

“…Using a rat model with a skeletal muscle injury, the regeneration of the skeletal muscle was enhanced by both periodic electrostimulation and the release of the anti‐inflammatory drug, the first regulating the behavior of the cells and the latter prohibiting the inflammation. [ 26 ] In other research, solid MNs for delivering drug to other body organs were used by developing an eye patch composed of a detachable MN array which is able to penetrate the tissue of the ocular surface and deliver the drug in a controlled manner (Figure 3B). Corneal neovascularization was used as a model for the disease with the results showing that the patch, when delivering antiangiogenic monoclonal antibody (DC101), reduced the neovascular area by ≈90%.…”

“…Reproduced with permission. [ 26 ] Copyright 2022, American Chemical Society. B) Eye patch composed of detachable MNs array to penetrate the tissue of the ocular surface and deliver drug in a controlled manner.…”

“…Therapeutic biomedical applications: Reproduced with permission. [26][27][28] Copyright 2022, American Chemical Society. Copyright 2021, American Chemical Society.…”

Microneedles for in situ tissue regeneration

“…MNs can overcome necrotic tissue barriers or microbial membranes to deliver active substances minimally invasively to deep local tissues [ 44 , 45 ]. In addition, through the rational design of needle tips structure and basing, controlled release of active substances can be achieved conveniently and effectively.…”