Implantable enzyme amperometric biosensors

Kotanen, Christian N.; Moussy, Francis; Carrara, Sandro; Guiseppi‐Elie, Anthony

doi:10.1016/j.bios.2012.03.016

Cited by 134 publications

(93 citation statements)

References 141 publications

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“…The major mechanism of failure is the biodegradation of the sensing layer and the changing diffusional barrier that arises from the host's response toward the implanted sensor (12). Current devices cannot be used for prolonged periods of measurement because of endogenous interferences, fouling, and so on (13)(14)(15).…”

Section: Key Challenges In Molecular Sensing For Biomedical Applicationsmentioning

confidence: 99%

“…It should also be noted that, if hydrogen peroxide is developed as a by-product of the oxidase enzymatic substrate conversion during the sensor activity, this compound can cause the overoxidation of the CP and limit the lifetime of the sensor (12). Therefore, the sensor requires careful designing in order to minimize H 2 O 2 formation.…”

Section: Conducting Polymers In Biosensorsmentioning

confidence: 99%

See 1 more Smart Citation

Properties and Customization of Sensor Materials for Biomedical Applications

Zuliani¹,

Curto²,

Matzeu³

et al. 2014

Comprehensive Materials Processing

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Section: Key Challenges In Molecular Sensing For Biomedical Applicationsmentioning

confidence: 99%

Section: Conducting Polymers In Biosensorsmentioning

confidence: 99%

Properties and Customization of Sensor Materials for Biomedical Applications

Zuliani¹,

Curto²,

Matzeu³

et al. 2014

Comprehensive Materials Processing

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“…[1][2][3][4] In particular, the development of biosensors with rapidity of measurement and high sensitivity for glucose detection is important in biological and clinical fields, because glucose plays a crucial role in life processes and its concentration in blood is usually used as a clinical indicator of diabetes. 5,6 However, the challenge existing in biosensor fabrication is to provide a suitable microenvironment for the immobilized enzymes on the electrode surface that present the full functionality of the biomolecules over a long time.…”

Section: Introductionmentioning

confidence: 99%

Development of Highly Sensitive Amperometric Biosensor for Glucose Using Carbon Nanosphere/Sodium Alginate Composite Matrix for Enzyme Immobilization

Han

Cai

et al. 2014

ANAL. SCI.

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In this study, we developed a highly sensitive amperometric biosensor for glucose detection based on glucose oxidase immobilized in a novel carbon nanosphere (CNS)/sodium alginate (SA) composite matrix. This hybrid material combined the advantages of CNS and natural biopolymer SA. This composite film was characterized by scanning electron microscope, electrochemical impedance spectroscopy and UV-vis, which indicated that the hybrid material was suitable for immobilization of glucose oxidase. Various experimental conditions were investigated that influenced the performance of the biosensor, such as pH, applied potential and temperature. Under the optimum conditions, the biosensor showed excellent performance for glucose over a wide linear concentration range from 1.0 × 10 -6 to 4.6 × 10 -3 M with a detection limit of 0.5 μM based on a signal-to-noise ratio of 3. Furthermore, the biosensor exhibited excellent long-term stability and satisfactory reproducibility.

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“…Several attempts have been made to integrate electrochemical sensors in order to determine the content of biological analyte [1][2][3][4]. The ability of an electrochemical system to perceive small changes in the signal brings uncertainty and limits the sensor to make precise measurements.…”

Section: Introductionmentioning

confidence: 99%