Implantable insulin pumps and metabolic control

Abstract

SummaryThe development of implantable, remotecontrolled insulin pumps dates back to the early 1970's when it was recognized that conventional insulin therapy may be inadequate to control microvascular complications. For the first prototypes the intraperitoneal access route was favoured because of a physiological portal/peripheral insulin gradietlt. With intraperitoneal insulin delivery excellent metabolic control can be obtained with glycohaemoglobin values close to the upper normal range. A1-though long-term studies in insulin-dependent diabetic patients show comparable results with respect to glycaem~e control and intermediary substrate levels with intensive conventional therapy, the advantage of intraperitoneal insulin delivery may lie in the low rate of hypoglycaemic episodes. [Diabetologia (1994)

Efficient Gene Transfer into Macrophages and Dendritic Cells by in Vivo Gene Delivery with Mannosylated Lipoplex via the Intraperitoneal Route

“…Regarding the i.p. administration method, implantable infusion pumps have been developed for a number of diseases (Hepp, 1994), and there has been remarkable progress in endoscopic and laparoscopic surgical techniques (Stellato, 1992). This progress in surgical techniques and devices could make i.p.…”

Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice

“…Recently, implantable infusion pumps have been developed for the treatment of several diseases, 26) and endoscopic and laparoscopic surgical techniques have made remarkable progress. 27) Furthermore, continuous ambulatory peritoneal dialysis is an extremely common treatment modality for end-stage renal failure, 28) indicating that techniques for inserting catheters in intraperitoneal cavity will advance in the future.…”

Effect of the Absorption Enhancer Saponin on the Intrarenal Distribution of 5-Fluorouracil Following Its Kidney Surface Application in Rats

“…7) Recently, implantable infusion pumps have been developed for the treatment of several diseases, 8) and remarkable progress has been made in endoscopic and laparoscopic operation techniques. 9,10) Furthermore, continuous ambulatory peritoneal dialysis is an extremely common treatment modality for end stage renal failure 11) ; consequently, the skill needed for inserting the catheter on the intraperitoneal organs should be improved in the future.…”