Implantable Monitoring System for Rodents

Kilinc, Enver G.; Dehollain, Catherine; Maloberti, Franco

doi:10.1007/978-3-319-21179-4_2

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…This tether can restrict the movement of the animals, potentially distressing them, whilst also creating uncertainties in chronic behavioural studies in neurophysiology [4]. Removing the tethering in favour of batteries mitigates these issues, as well as decreasing the risk of infection, but at a cost of limiting the study to a short time period and increasing the mass and volume of the implant [5].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Implantable Antennas for Exploratory Neuroscience Studies

Doychinov

Russell

Somjit

et al. 2018

Loughborough Antennas &Amp; Propagation Conference 2018 (LAPC 2018)

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Section: Introductionmentioning

confidence: 99%

Investigation of Implantable Antennas for Exploratory Neuroscience Studies

Doychinov

Russell

Somjit

et al. 2018

Loughborough Antennas &Amp; Propagation Conference 2018 (LAPC 2018)

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Non-contact capacitive sensing for ECG recording in small animals

Wang

Lin

2020

Meas. Sci. Technol.

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Rat electrocardiography (ECG) is frequently used in biomedical research as a model for exploring heart function in a wide variety of experimental conditions. Subcutaneous ECG is a common approach to record rat heart rhythm using implanted needle electrodes to sense the rat ECG signals with the animal under deep anesthesia. However, such an invasive measurement could cause inconvenience due to cumbersome animal preparation, and the anesthetics are likely to interfere with the autonomic regulation of cardiac rhythm. Most studies used the galvanic contact between animal limb and electrode sensing surface to record cardiac signals from small animals. However, the non-contact approach of capacitive ECG sensing for small laboratory animals has not been extensively investigated. This study aims to develop a non-contact ECG system to promote the ECG measurement of laboratory animals for biomedical research. The method utilizes the capacitive coupling technique to detect cardiac signals in awake rats (R-wave amplitude of only 0.2 mV) through a non-conductive layer. The proposed system generates non-contact ECG signals with distinguishable R-peaks at a limb-electrode capacitance above 8.5 pF and maximum through-thickness of the non-conductive layer of 0.4 mm for heart rate assessment. In conclusion, this study provides non-contact ECG monitoring based on capacitive electrodes to improve the throughput of ECG measurement procedures for biomedical research and establish a lower bound of coupling capacitance for non-contact application to heart rate. The new method is ideally suited for the rapid evaluation of autonomic regulation of heart rhythm in awake laboratory small animals.

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Implantable Monitoring System for Rodents

Cited by 2 publications

References 34 publications

Investigation of Implantable Antennas for Exploratory Neuroscience Studies

Investigation of Implantable Antennas for Exploratory Neuroscience Studies

Non-contact capacitive sensing for ECG recording in small animals

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