Implantable, multifunctional, bioresorbable optics

Tao, Hu; Kainerstorfer, Jana M.; Siebert, Sean; Pritchard, Eleanor M.; Sassaroli, Angelo; Panilaitis, Bruce; Brenckle, Mark A.; Amsden, Jason J.; Levitt, Jonathan M.; Fantini, Sergio; Kaplan, David L.; Omenetto, Fiorenzo G.

doi:10.1073/pnas.1209056109

Cited by 114 publications

(110 citation statements)

References 33 publications

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“…More recently, extensive research was performed on silk-based materials [1,9] and hydrogels [2]. Spider silks, in particular, are specifically effective for implantable sensing devices [1], while hydrogels are studied for applications in Optogenetics, cellular scaffolding [10] or photochemical tissue bonding [6].…”

Section: Introductionmentioning

confidence: 99%

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Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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Section: Introductionmentioning

confidence: 99%

“…Several bioresorbable optical components have been developed, such as microlens arrays [2], diffraction gratings [3], reflective plates [1], photonic crystals [4], waveguides [5,6] and optical fibers [7,8].…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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“…2). This device was biodegradable and has been implanted subcutaneously in mice [37]. In vivo tests in mice showed up to a threefold enhancement in reflectivity of bare tissue, which would be beneficial for imaging and sensing.…”

Section: Diffraction Grating Reflectorsmentioning

confidence: 99%

“…Silk films can also be generated with features down to tens of nanometers in size, which is ideal for optical applications such as diffraction gratings. Silk has been used to create various biocompatible optical devices, including microlens arrays, microprism arrays, and diffraction gratings [19,[37][38][39].…”

Section: Biocompatible and Biodegradable Materialsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…Recently, optical clarity and good processability have reinvented silk as a material for high-technology, biooptical elements such as lenses, lasers, PhCs, and plasmonic resonators (11)(12)(13)(14)(15)(16)(17)(18). Due to the combination of favorable material traits, silk shows promise for use in optical elements for biomedical application.…”

mentioning

confidence: 99%

Deformable and conformal silk hydrogel inverse opal

Min

Kim

2017

Proc. Natl. Acad. Sci. U.S.A.

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Photonic crystals (PhCs) efficiently manipulate photons at the nanoscale. Applying these crystals to biological tissue that has been subjected to large deformation and humid environments can lead to fascinating bioapplications such as in vivo biosensors and artificial ocular prostheses. These applications require that these PhCs have mechanical durability, deformability, and biocompatibility. Herein, we introduce a deformable and conformal silk hydrogel inverse opal (SHIO); the photonic lattice of this 3D PhC can be deformed by mechanical strain. This SHIO is prepared by the UV cross-linking of a liquid stilbene/silk solution, to give a transparent and elastic hydrogel. The pseudophotonic band gap (pseudo-PBG) of this material can be stably tuned by deformation of the photonic lattice (stretching, bending, and compressing). Proof-of-concept experiments demonstrate that the SHIO can be applied as an ocular prosthesis for better vision, such as that provided by the tapeta lucida of nocturnal or deep-sea animals.silk fibroin | photonic crystal | photo-cross-linking | ocular prosthesis | intraocular pressure sensor

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Implantable, multifunctional, bioresorbable optics

Cited by 114 publications

References 33 publications

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Toward biomaterial-based implantable photonic devices

Deformable and conformal silk hydrogel inverse opal

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