Implantable Nanosensors: Toward Continuous Physiologic Monitoring

Ruckh, Timothy T.; Clark, Heather A.

doi:10.1021/ac402688k

Cited by 64 publications

(53 citation statements)

References 98 publications

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“…silica) materials are not fully compatible with biological systems for implanting in vivo . [1b, 16] Solid-state optical fibers may cause infection and immune reactions (foreign body responses) at an implanted site, resulting in inflammation and discomfort to patients. [17] This necessitates the development of biocompatible implantable biosensors.…”

mentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

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confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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“…While recognizing RSA as the current ''gold standard'' for detecting micromotion and predicting aseptic loosening, recent advances in wireless and nanotechnology sensors offers the potential for accurately monitoring motion, stress, and biochemical variables that correlate with aseptic loosening of a broad range of cemented hip stem designs [2,4,6]. Evaluating the safety, accuracy, cost, and accessibility of alternative component monitoring technologies would be some worthwhile next steps.…”

Section: Where Do We Need To Go?mentioning

confidence: 99%

CORR Insights®: Early Subsidence Predicts Failure of a Cemented Femoral Stem With Minor Design Changes

Beringer

2016

Clinical Orthopaedics &Amp; Related Research

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“…Nanosensors for continuous monitoring of physiological processes (eg, measurement of glucose, lactate, urea, fatty acids, measurement of brain activity and autonomic functions) [24][25][26][27] Of all these options the reaction that is of most interest in the field of diabetes technology is the development of glucose sensors for continuous glucose monitoring.…”

Section: Nanotechnology In Medicinementioning

confidence: 99%

Options for the Development of Noninvasive Glucose Monitoring

Thomas

Heinemann

Ramírez

et al. 2015

J Diabetes Sci Technol

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Nowadays nanotechnology has many applications in products used in various areas of daily life; however, this technology has also an option in modern medicine and pharmacy. Therefore, this technology is also an attractive option for the field of diagnosis and treatment of diabetes. Many people with diabetes measure their blood glucose levels regularly to determine the insulin dose. Ideally glucose values would be measured noninvasively (NI). However, none of all the NI approaches studied in the past decades enabled reliable NI measurements under all daily life conditions. Particularly an unfavorable signal-to-noise ratio turned out to be problematic. Based on the known physical possibilities for NI glucose monitoring the focus of this review is on nanotechnology approaches. Functional prototypes exist for some of these that showed promising results under defined laboratory conditions, indicating a good sensitivity and selectivity for glucose. On the second hand is to optimize the technological process of manufacturing. In view of the rapid progress in micro-and nanoelectronics hopefully NI glucose monitoring systems can be developed in the near future.

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Implantable Nanosensors: Toward Continuous Physiologic Monitoring

Cited by 64 publications

References 98 publications

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

CORR Insights®: Early Subsidence Predicts Failure of a Cemented Femoral Stem With Minor Design Changes

Options for the Development of Noninvasive Glucose Monitoring

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