2021
DOI: 10.3390/metabo11030176
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Implantable NMR Microcoils in Rats: A New Tool for Exploring Tumor Metabolism at Sub-Microliter Scale?

Abstract: The aim of this study was to evaluate the potential of a miniaturized implantable nuclear magnetic resonance (NMR) coil to acquire in vivo proton NMR spectra in sub-microliter regions of interest and to obtain metabolic information using magnetic resonance spectroscopy (MRS) in these small volumes. For this purpose, the NMR microcoils were implanted in the right cortex of healthy rats and in C6 glioma-bearing rats. The dimensions of the microcoil were 450 micrometers wide and 3 mm long. The MRS acquisitions we… Show more

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Cited by 4 publications
(6 citation statements)
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References 24 publications
(26 reference statements)
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“…The NMR detection volume reported here for the implanted device was found to be similar to those measured previously 14 , 15 , of the order of 1 μL, when evaluated by FEM modeling or measured by MRI. Comparison of the detection sensitivity obtained with the microcoil of the implanted device and a commercial surface coil designed for rat brain confirmed the importance of miniaturization to achieve sufficient sensitivity in the vicinity of the capillary used for CED.…”
Section: Discussionsupporting
confidence: 84%
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“…The NMR detection volume reported here for the implanted device was found to be similar to those measured previously 14 , 15 , of the order of 1 μL, when evaluated by FEM modeling or measured by MRI. Comparison of the detection sensitivity obtained with the microcoil of the implanted device and a commercial surface coil designed for rat brain confirmed the importance of miniaturization to achieve sufficient sensitivity in the vicinity of the capillary used for CED.…”
Section: Discussionsupporting
confidence: 84%
“…We have previously reported results obtained with brain-implanted microcoils of comparable size in healthy and tumor-bearing rats 14 , 15 . In these studies, the concentrations, relative to tCr, of tCho, glutamine, glutamate, lactate, mI, tNAA and taurine obtained in the brain of healthy animals with the implanted microcoil were similar to those reported in the literature using standard extracorporeal NMR coils.…”
Section: Discussionmentioning
confidence: 99%
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“…A microcoil configuration close to the implanted microcoil of the device was previously investigated 12,13 . The results reported on healthy animals and tumor-bearing animals demonstrated the feasibility of the approach and the key role played by the miniaturization of the coil for enhancing the detection sensitivity on very small volume.…”
Section: Discussionmentioning
confidence: 99%
“…One solution to this sensitivity limitation is to design a dedicated NMR coil whose dimensions correspond to the volume to be examined, and to position it as close as possible to the region of interest. Reducing the size of the RF coil advantageously translates into an increase in coil sensitivity per unit volume, while positioning it in close proximity to the region of interest optimizes detection sensitivity in this region [9][10][11][12][13] .…”
Section: Introductionmentioning
confidence: 99%