Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Zhou, Yuhao; Ji, Bowen; Wang, Minghao; Zhang, Kai; Huangfu, Shuaiqi; Feng, Huicheng; Chang, Honglong; Yuan, Xiaohui

doi:10.3390/coatings11020204

Cited by 9 publications

(5 citation statements)

References 117 publications

(186 reference statements)

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“…Recently, excellent progress has been achieved toward developing implantable miniature wireless ES devices ( 64 ). Furthermore, the development of soft and electroactive biomaterials has reduced the physical mismatch at the tissue-device boundary ( 65 ), thereby making long-term electroceutical treatment more viable. It should be noted that ES devices have been considerably developed toward neuromodulation, and skeletal muscle stimulation has received relatively less attention.…”

Section: Discussionmentioning

confidence: 99%

Silver electroceutical technology to treat sarcopenia

Kim

Cho

Yang

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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While the world is rapidly transforming into a superaging society, pharmaceutical approaches to treat sarcopenia have hitherto not been successful due to their insufficient efficacy and failure to specifically target skeletal muscle cells (skMCs). Although electrical stimulation (ES) is emerging as an alternative intervention, its efficacy toward treating sarcopenia remains unexplored. In this study, we demonstrate a silver electroceutical technology with the potential to treat sarcopenia. First, we developed a high-throughput ES screening platform that can simultaneously stimulate 15 independent conditions, while utilizing only a small number of human-derived primary aged/young skMCs (hAskMC/hYskMC). The in vitro screening showed that specific ES conditions induced hypertrophy and rejuvenation in hAskMCs, and the optimal ES frequency in hAskMCs was different from that in hYskMCs. When applied to aged mice in vivo, specific ES conditions improved the prevalence and thickness of Type IIA fibers, along with biomechanical attributes, toward a younger skMC phenotype. This study is expected to pave the way toward an electroceutical treatment for sarcopenia with minimal side effects and help realize personalized bioelectronic medicine.

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Section: Discussionmentioning

confidence: 99%

Silver electroceutical technology to treat sarcopenia

Kim

Cho

Yang

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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“…It was gradually discovered that electrical stimulation of damaged neural tissue causes deep cellular alterations associated with regeneration and repair. 8,83 Research with in vitro and in vivo models has confirmed that the depolarizing current applied to the site of the damaged axon has a significant effect on axon germination and regeneration. 84 In this regard, functional hydrogels have become promising bioelectronics and biomedical engineering candidates, with more focus dedicated to solving neurological problems.…”

Section: Conductive Hydrogel-based Neural Interfacesmentioning

confidence: 99%

Advances in conductive hydrogels for neural recording and stimulation

Dawit,

Zhao,

Wang

et al. 2024

Biomater. Sci.

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“…b) Reproduced under the terms of the CC‐BY Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0). [ 204 ] Copyright 2021, The Authors, published by MDPI. c) Reproduced with permission from Mark Stone/University of Washington.…”

Section: Surface Electrode Arrays For the Central And Peripheral Nerv...mentioning

confidence: 99%

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

Tringides

Mooney

2022

Advanced Materials

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with the outermost layer of biological tissues, often spanning a significant surface area. Devices typically have multiple electrodes that aim to monitor and modulate cells and tissues in a minimally invasive manner, using biomaterials designed to evoke minimal inflammatory responses. Applications of Surface Electrode Arrays RecordingBecause surface electrode arrays can record a "snapshot" of the electrical activity at distinct locations, these arrays are useful to monitor the function of a tissue. Though the recordings are typically local field potentials, with electrodes that are small enough to modulate as little of a location as possible while still maintaining a sufficiently high conductivity, single units from individual cells have been reported. Clinically, these recordings are used to map the epicardial surface to identify instances, and potentially mechanisms, of chronic atrial fibrillation, [1] dysfunction of ventricular tachycardia caused by congenital defects, [2] and other abnormal conduction conditions in the cardiac system. Clinical electrocorticogram (ECoG) is used to identify similar functional changes on the cortical surface of the brain, most commonly to identify epileptic focal center(s), or detect seizure activity. [3][4][5][6][7] Other functional uses of ECoG include intraoperative monitoring during tumor resection. [8] A surgeon can ask a patient to perform an activity such as a speech and then identify and avoid the active cortical regions during surgery, to avoid major disruptions to the patient quality of life. StimulationInstead of passively monitoring electrical activity, multielectrode surface arrays can provide electrical current to the underlying tissue and induce a desired excitatory or inhibitory response. The applications for stimulating surface electrode arrays are often therapeutic and include implantable pacemakers, which restore a normal cardiac rhythm by providing external and overriding cues to the cardiomyocytes responsible for establishing a sinus rhythm. [9] Pulses delivered to specific regions of the spinal cord are used to manage chronic pain, [10][11][12] and more recently as a therapy to promote neuronal plasticity in Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely manipulated ductile metal films, which offer limited stretchability. However, the living tissues to which they are applied are nonlinear viscoelastic materials, which can undergo significant mechanical deformation in dynamic biological environments. Further, the same arrays and compositions are often repurposed for vastly different tissues rather than optimizing the materials and mechanical properties of the implant for the target application. By first characterizing the desired biological environment, and then designing a technology for a particular organ, surface electrode arrays may be more conformable, and offer better interfaces to tissues while causing less damage. Here, the various materials used in each component of a surface electrode array are first r...

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Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Cited by 9 publications

References 117 publications

Silver electroceutical technology to treat sarcopenia

Silver electroceutical technology to treat sarcopenia

Advances in conductive hydrogels for neural recording and stimulation

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

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