Implantateinheilung

Klein, Martine; Al‐Nawas, Bilal; Popović‐Bijelić, Ana; Wörsdörfer, Nora; Götz, Hermann; Sandhöfer, Falk; Wagner, Wilfried; Duschner, H.; Mainz,

doi:10.1515/biomat.2006.7.4.291

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…COL I deposition was higher on the untreated micropillar arrays except P8G8 than their plasma treated counterparts, while OP deposition was higher on plasma treated substrates (except P16G16). Surface hydrophilicity was shown to enhance deposition of OP both in vitro [104] and in vivo [105] because of higher BMP signaling on hydrophilic surfaces.…”

Section: Bone Extracellular Matrix Deposition and Mineralizationmentioning

confidence: 99%

Square prism micropillars on poly(methyl methacrylate) surfaces modulate the morphology and differentiation of human dental pulp mesenchymal stem cells

Hasturk

Ermis

Demirci

et al. 2019

Colloids and Surfaces B: Biointerfaces

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Use of soluble factors is the most common strategy to induce osteogenic differentiation of mesenchymal stem cells (MSCs) in vitro, but it may raise potential side effects in vivo. The topographies of the substrate surfaces affect cell behavior, and this could be a promising approach to guide stem cell differentiation. Micropillars have been reported to modulate cellular and subcellular shape, and it is particularly interesting to investigate whether these changes in cell morphology can modulate gene expression and lineage commitment without chemical induction. In this study, poly(methyl methacrylate) (PMMA) films were decorated with square prism micropillars with different lateral dimensions (4, 8 and 16 μm), and the surface wettability of the substrates was altered by oxygen plasma treatment. Both pattern dimensions and hydrophilicity were found to affect the attachment, proliferation, and most importantly, gene expression of human dental pulp mesenchymal stem cells (DPSCs). Decreasing the pillar width and interpillar *

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Section: Bone Extracellular Matrix Deposition and Mineralizationmentioning

confidence: 99%