Implantation

Finn, C. A.

doi:10.1007/978-94-011-1286-4_3

Marshall’s Physiology of Reproduction 1994

DOI: 10.1007/978-94-011-1286-4_3

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Implantation

C. A. Finn¹

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Cited by 2 publications

(1 citation statement)

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“…Other than these data, knowledge is very limited regarding the potential role of EDNs and other vasomodulatory factors in the uterus and utero-placental (Ut-Pl) units during implantation and placentation in the canine species. However, especially when the invasive, endotheliochorial type of canine placentation is taken into consideration, adequate proliferation and invasion of trophoblasts must be critical for the species-specific decidualization, implantation and placentation in dogs [ 14 , 15 , 16 ].…”

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confidence: 99%

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

Gram

Boos

Kowalewski

2017

Journal of Reproduction and Development

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Utero-placental (Ut-Pl) angiogenesis and blood flow are fundamental for successful outcome of pregnancy. They are controlled by numerous vasodilator and vasoconstrictor systems such as endothelins (EDNs) and the renin angiotensin system. Dogs possess an invasive type of placentation, classified as endotheliochorial. Despite increasing knowledge regarding canine Ut-Pl function, little information exists on uterine and placental vascular activity during initiation, maintenance and termination of pregnancy in this species. The current study investigated expression of EDNs and their receptors (EDNRA and EDNRB) in the pre-implantation uterus and Ut-Pl compartments during gestation and at normal parturition, as well as in mid-pregnant dogs treated with the antigestagen aglepristone. The Ut-Pl mRNA expression of EDN1 and EDNRA was constant until mid-gestation and increased significantly during prepartum luteolysis. In contrast, EDN2 was highest pre-implantation and decreased following placentation, remaining low thereafter. Expression of the EDN-activating enzyme ECE1 and mRNA of EDNRB increased towards mid-gestation and was further elevated at prepartum luteolysis. Antigestagen treatment resulted in increased levels of EDN1 and EDNRA. At the cellular level, the uterine expression of EDN1, ECE1 and EDNRB was found predominantly in the endometrial surface and glandular epithelial cells; uterine signals for EDNRA were weak. In Ut-Pl all targets were mainly localized in the placenta fetalis, with syncytiotrophoblast staining stronger for ECE1 and EDNRB. In contrast, EDNRA stained strongly at the base of the placental labyrinth. Expression and localization of EDNs (EDN1, -2), EDN receptors and ECE1 in the placenta fetalis suggests their involvement in the trophoblast invasion and proliferation.

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mentioning

confidence: 99%

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

Gram

Boos

Kowalewski

2017

Journal of Reproduction and Development

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The role of trophoblast in the physiological change in decidual spiral arteries

et al. 1999

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The remodelling of the maternal uterine spiral arteries during pregnancy, known as physiological change, is critical for the normal growth and development of the fetus. Controversy has surrounded the part played by fetal trophoblast in the transformation of these spiral arteries. To address this debate, a histological and immunochemical comparison of blood vessels from the implantation sites of human pregnancies of early gestation with uterine tissue where trophoblast was absent was performed. Results showed that true physiological change, with the features of medial necrosis and deposition of fibrinoid material, only occurred in the presence of trophoblast. In addition, it was found that subpopulations of trophoblast contribute differently in the process. Interstitial trophoblast-mediated destruction of the arterial media precedes replacement of the endothelial cells by endovascular trophoblast.

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Implantation

Cited by 2 publications

References 498 publications

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

The role of trophoblast in the physiological change in decidual spiral arteries

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