Implantation of a refillable glucose monitoring-telemetry device

Атанасов, Пламен; Yang, Saipeng; Salehi, C.; Ghindilis, Andrey L.; Wilkins, Ebtisam; Schade, David S.

doi:10.1016/s0956-5663(97)00025-0

Cited by 31 publications

(13 citation statements)

References 44 publications

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“…This reaction continues for 1-2 weeks ultimately resulting in fibrous encapsulation of the implanted material (final stage of wound healing in response to implanted, non-degradable foreign material). The extent and progression of the inflammatory process is dictated by the nature of the implant, specifically size, shape, physical (such as surface structure and morphology) and chemical (presence of charge, hydrophobic or hydrophilic nature, sterilisation) properties [92,93].…”

Section: Biocompatibility and Implantable Biosensorsmentioning

confidence: 99%

Biosensor Design with Molecular Engineering and Nanotechnology

Johnson

Trzebinski

et al. 2014

Body Sensor Networks

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The concept of a biosensor is well established and the idea of integrating a molecular recognition layer with a base sensor, such that analyte binding or reaction at the former results in a measureable change (in current or voltage) in the latter has seen many ingenious embodiments. Despite this and the huge amount of research worldwide in biosensors, as outlined in Chap. 2, many challenges still remain in building reliable, long-lived biosensors, especially in the hostile environment of the human body. The enormous potential for in vivo sensing of pathophysiological molecules over time and space has led to many attempts to achieve this and the rewards, both in terms of clinical benefit and improved understanding, cannot be underestimated. As new tools for producing biosensors become available, they are rapidly recruited. In recent years, developments in two areas of science and engineering have provided new opportunities to look again at how biosensors are built and deployed. These developments were not driven by the needs of those building and using biosensors but by much broader scientific and technological trends, which nonetheless have found ready applicability in this area.One of the trends is an increasing knowledge of the structural factors that determine function in biological macromolecules and the other is the appreciation that the properties of materials with a characteristic length scale from 1 to 100 nm are not those expected from dividing macroscopic materials into smaller pieces nor those expected from adding atoms or molecules together. The first of these trends is sometimes referred to as biomolecular engineering and the second as nanotechnology.There are many drivers for the use of molecular engineering and nanotechnology in the design and application of biosensors and the past decade has seen these tools

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Section: Biocompatibility and Implantable Biosensorsmentioning

confidence: 99%

Biosensor Design with Molecular Engineering and Nanotechnology

Johnson

Trzebinski

et al. 2014

Body Sensor Networks

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“…23). Even though an actual, chronic artificial pancreas has not been developed yet, glucose-sensing implants have constantly increased in numbers and improved over the years [4,5].…”

Section: Artificial Pancreasmentioning

confidence: 99%

DeSyRe: On-demand system reliability

Sourdis

Strydis²,

Armato³

et al. 2013

Microprocessors and Microsystems

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a b s t r a c tThe DeSyRe project builds on-demand adaptive and reliable Systems-on-Chips (SoCs). As fabrication technology scales down, chips are becoming less reliable, thereby incurring increased power and performance costs for fault tolerance. To make matters worse, power density is becoming a significant limiting factor in SoC design, in general. In the face of such changes in the technological landscape, current solutions for fault tolerance are expected to introduce excessive overheads in future systems. Moreover, attempting to design and manufacture a totally defect-/fault-free system, would impact heavily, even prohibitively, the design, manufacturing, and testing costs, as well as the system performance and power consumption. In this context, DeSyRe delivers a new generation of systems that are reliable by design at well-balanced power, performance, and design costs. In our attempt to reduce the overheads of fault-tolerance, only a small fraction of the chip is built to be fault-free. This fault-free part is then employed to manage the remaining fault-prone resources of the SoC. The DeSyRe framework is applied to two medical systems with high safety requirements (measured using the IEC 61508 functional safety standard) and tight power and performance constraints.

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“…Multilayer structures were prepared by first dispersing SWNT in 40 mL of Milli-Q water with 1% Triton X-100 for 1.20 hours under ultrasonication, and then followed by vacuum filtration using platinum coated PVDF membranes. The PPy layers were electrodeposited at 1 mA/cm 2 . The surface morphology of prepared multilayer structures was studied using scanning electron microscopy.…”

Section: Preparation Of Swnt-ppy Multilayer Structuresmentioning

confidence: 99%

Amperometric Glucose Biosensor on Layer by Layer Assembled Carbon Nanotube and Polypyrrole Multilayer Film

2008

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An amperometric glucose biosensor on layer by layer assembled carbon nanotube and polypyrrole multilayer film has been reported in the present investigation. Homogeneous and stable single wall carbon nanotubes (SWNTs) and polypyrrole (PPy) multilayer films were alternately assembled on platinum coated Polyvinylidene fluoride (PVDF) membrane. Since conducting polypyrrole has excellent anti-interference ability, protection ability in favor of increasing the amount of the SWNTs on platinum coated PVDF membrane and superior transducing ability, a layer by layer approach of polypyrrole and carbon nanotubes has provided an excellent matrix for the immobilization of enzyme. The layer-by-layer assembled SWNTs and PPy-modified platinum coated PVDF membrane is shown to be an excellent amperometric sensor over a wide range of concentrations of glucose. The glucose oxidase (GOx) was immobilized on layer by layer assembled film by a physical adsorption method by cross linking through Glutaraldehyde. The glucose biosensor exhibited a linear response range from 1 mM to 50 mM of glucose concentration with excellent sensitivity of 7.06 mA/mM.

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Implantation of a refillable glucose monitoring-telemetry device

Cited by 31 publications

References 44 publications

Biosensor Design with Molecular Engineering and Nanotechnology

Biosensor Design with Molecular Engineering and Nanotechnology

DeSyRe: On-demand system reliability

Amperometric Glucose Biosensor on Layer by Layer Assembled Carbon Nanotube and Polypyrrole Multilayer Film

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