Implantation of an intracerebral cannula in the mouse

Boschi, G; Launay, Nicole; Rips, Richard

doi:10.1016/0160-5402(81)90108-x

Cited by 17 publications

(10 citation statements)

References 1 publication

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“…Central injections were made after a guide cannula had been implanted into the right lateral ventricle using a method described previously (Boschi et al, 1981). One week later, the drugs were injected in a volume of 0.5 to 1 d1 over a period of 50 to I00s.…”

Section: Injectionsmentioning

confidence: 99%

Neuroleptic‐induced hypothermia in mice: lack of evidence for a central mechanism

Boschi

Launay

Rips

1987

British J Pharmacology

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1 The present study investigated the ability of neuroleptic drugs to induce hypothermia in mice when they were administered intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.). 2 Twelve neuroleptics belonging to five chemical classes including phenothiazines, butyrophenones, benzamides, thioxanthenes and diphenylbutylpiperidines were injected i.p. All of them, except benzamides, induced a dose-dependent decrease in rectal temperature. 3 Neuroleptics were administered i.c.v. via cannulae previously implanted in mice to determine whether this response might have a central origin. None of the drugs tested induced hypothermia at doses which did not produce toxic effects. These negative results suggest that neuroleptics act to elicit hypothermia via a peripheral, rather than a central mechanism. 4 Since some neuroleptics possess a-adrenolytic properties which could induce hypothermia by promoting vasodilatation, we attempted to antagonize the hypothermia produced by peripheral administration of two neuroleptics with phenylephrine, an a-adrenoceptor agonist that does not cross the blood-brain barrier. The hypothermia induced by both chlorpromazine and haloperidol was attenuated by phenylephrine, supporting the view that peripheral a-adrenoceptors may mediate neuroleptic-induced hypothermia.

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Section: Injectionsmentioning

confidence: 99%

Neuroleptic‐induced hypothermia in mice: lack of evidence for a central mechanism

Boschi

Launay

Rips

1987

British J Pharmacology

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“…For the central injections, a cannula was implanted into the right lateral ventricle of mice aged 5 weeks (Boschi, Launay & Rips, 1981). The drugs were injected in a volume of 0.5 ljl over a period of 50 s.…”

Section: Injectionsmentioning

confidence: 99%

Antinociceptive properties of thyrotropin releasing hormone in mice: comparison with morphine

Boschi

Desiles

Reny

et al. 1983

British J Pharmacology

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“…One possible explanation may lie in the fact that the back-ground quantity of endogenous opiates in unstressed animals is small so that their analgesic effect is only slightly potentiated by TRH and is undetectable in a test involving acute pain. The decrease in reaction latency may be attributed to other central effects of TRH such as the facilitating effect on spinal reflexes [8] and the hyperthermal effect [6]. A rise of temperature in the taft skin of an animal has been shown to result in a shortened latency of the tail-flick response [15].…”

Section: Resultsmentioning

confidence: 99%

Potentiating effect of thyrotropin-releasing hormone and of its synthetic analog digipramine on morphine-induced analgesia

et al. 1994

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Implantation of an intracerebral cannula in the mouse

Cited by 17 publications

References 1 publication

Neuroleptic‐induced hypothermia in mice: lack of evidence for a central mechanism

Neuroleptic‐induced hypothermia in mice: lack of evidence for a central mechanism

Antinociceptive properties of thyrotropin releasing hormone in mice: comparison with morphine

Potentiating effect of thyrotropin-releasing hormone and of its synthetic analog digipramine on morphine-induced analgesia

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