Implantation of embryonic pancreas in the anterior chamber of the eye in normal and diabetic rats

Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose

“…Thus, isolated islets in culture cannot capture the full complexity that determines insulin secretion in vivo. Pancreatic slice cultures [12][13][14] and islets implanted in the anterior chamber of the eye [15][16][17][18][19] have more recently been developed to try and provide a more physiological and "in context" environment. Although these methods have proven immensely valuable, they are not without caveats and still differ significantly from the normal physiological environment 20 .…”