Implants as Sustained Release Delivery Devices for Vaccine Antigens

Engert, Julia

doi:10.1007/978-1-4939-1417-3_12

Cited by 4 publications

(6 citation statements)

References 52 publications

(83 reference statements)

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“…Experiments with the Georgia Institute of Technology patch and other dermal patches under development demonstrate immune responses comparable with the standard modes of injectable delivery [64,90,91]. There has also been considerable interest in exploring additional vaccine-delivery innovations such as sustainedrelease formulations and skin permeabilization techniques which could potentially be applicable for IPV and substantially reduce logistical challenges of IPV administration [65,66,92]. Proof-ofconcept information in humans with such devices and methods should be the next logical step, and …”

Section: Colombia-dominican Republicguatemala-panama India Bangladeshmentioning

confidence: 95%

Polio Vaccination: Past, Present and Future

et al. 2015

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Live attenuated oral polio vaccine (OPV) and inactivated polio vaccine (IPV) are the tools being used to achieve eradication of wild polio virus. Because OPV can rarely cause paralysis and generate revertant polio strains, IPV will have to replace OPV after eradication of wild polio virus is certified to sustain eradication of all polioviruses. However, uncertainties remain related to IPV's ability to induce intestinal immunity in populations where fecal-oral transmission is predominant. Although substantial effectiveness and safety data exist on the use and delivery of OPV and IPV, several new research initiatives are currently underway to fill specific knowledge gaps to inform future vaccination policies that would assure polio is eradicated and eradication is maintained.

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Section: Colombia-dominican Republicguatemala-panama India Bangladeshmentioning

confidence: 95%

Polio Vaccination: Past, Present and Future

et al. 2015

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“…The degradation or swelling of the polymer results in a slow‐release of the antigen (Engert, 2015). The choice of polymer primarily includes silicone, ethylene‐vinyl acetate co‐polymer, collagen, or PLGA (Engert, 2015). Furthermore, additives or excipients such as PEG are added as a pore‐forming agent (or porogen) to fine‐tune the release profile of the antigen (Herrmann et al, 2007; Schulze & Winter, 2009).…”

Section: Slow‐release Systemsmentioning

confidence: 99%

“…Furthermore, additives or excipients such as PEG are added as a pore‐forming agent (or porogen) to fine‐tune the release profile of the antigen (Herrmann et al, 2007; Schulze & Winter, 2009). Implants are prepared by different techniques like direct compression, melting/molding, extrusion and casting (Engert, 2015). Implantable systems have been extensively used for hormonal treatments, birth control, ocular treatment and controlled drug release (Engert, 2015; Palomba et al, 2012).…”

Section: Slow‐release Systemsmentioning

confidence: 99%

“…Implants are prepared by different techniques like direct compression, melting/molding, extrusion and casting (Engert, 2015). Implantable systems have been extensively used for hormonal treatments, birth control, ocular treatment and controlled drug release (Engert, 2015; Palomba et al, 2012). To date the use of the implants for prophylactic vaccines has seen limited investigation.…”

Section: Slow‐release Systemsmentioning

confidence: 99%

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Recent advancements in single dose slow‐release devices for prophylactic vaccines

Ray

Puente

Steinmetz

et al. 2022

WIREs Nanomed Nanobiotechnol

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Single dose slow-release vaccines herald a new era in vaccine administration. An ideal device for slow-release vaccine delivery would be minimally invasive and self-administered, making these approaches an attractive alternative for mass vaccination programs, particularly during the time of a pandemic. In this review article, we discuss the latest advances in this field, specifically for prophylactic vaccines able to prevent infectious diseases. Recent studies have found that slow-release vaccines elicit better immune responses and often do not require cold chain transportation and storage, thus drastically reducing the cost, streamlining distribution, and improving efficacy. This promise has attracted significant attention, especially when poor patient compliance of the standard multidose vaccine regimes is considered. Single dose slow-release vaccines are the next generation of vaccine tools that could overcome most of the shortcomings of present vaccination programs and be the next platform technology to combat future pandemics.

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“…Implants generally need to be given by injection, which is not preferred by patients and may be more complex and expensive to manufacture [10]. From a vaccine perspective, implants provide a single-shot approach reducing the need for booster doses, which are commonly required for traditional non-living vaccines in order to stimulate long-lasting immunity [11]. Unlike most drug implants, vaccine implants usually require the relatively short-term release of vaccine components in order to induce potent immune responses while avoiding tolerance (low doses of antigen for an extended period of time) or sequestration and/or deletion (higher amounts of antigen over an extended period of time) of lymphocytes [12].…”

Section: Introductionmentioning

confidence: 99%

Vaccine implants: current status and recent advancements

Bobbala

Hook

2020

Emerging Topics in Life Sciences

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Implants have long been used in the field of drug delivery as controlled release vehicles and are now being investigated as single-shot vaccine technologies. Implants have shown great promise, minimizing the need for multiple immunizations while stimulating potent immune responses with reduced doses of vaccine. Synchronous release of vaccine components from implants over an appropriate period of time is important in order to avoid issues including immune tolerance, sequestration or deletion. Traditionally, implants require surgical implantation and removal, which can be a barrier to their widespread use. Degradable and in situ implants are now being developed that can be administered using minimally invasive subcutaneous or intramuscular injection techniques. Injectable hydrogels remain the most commonly studied approach for sustained vaccine delivery due to their ease of administration and tunable degradation properties. Despite exciting advancements in the field of vaccine implants, few technologies have progressed to clinical trials. To increase the likelihood of clinical translation of vaccine implants, strategic testing of disease-relevant antigens in appropriate species is essential. In this review, the significance of vaccine implants and the different types of implants being developed to deliver vaccines are discussed.

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Implants as Sustained Release Delivery Devices for Vaccine Antigens

Cited by 4 publications

References 52 publications

Polio Vaccination: Past, Present and Future

Polio Vaccination: Past, Present and Future

Recent advancements in single dose slow‐release devices for prophylactic vaccines

Vaccine implants: current status and recent advancements

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