Observation result in cell biology (CB) learning showed that most students assumed cell biology as a complex and abstract material. The level of conceptual understanding was still relatively low observable from inadequate test results. Misconception on cell structure as a dense and non-porous structure was reported; this can be seen from students’ drawing on cell membranes. One solution to overcome the above problem was to develop contemporary teaching materials in the form of e-module based on Edmodo mobile (based android) so that students can easily access them by their smartphone. The research objective was to develop an Edmodo android cell biology module. Research and development (R&D) method were applied in this study. The development model used was Thiagarajan 4D, which is defined, design, and develop. The instruments used were the e-module validation questionnaire by experts (material and media experts, practitioners) and the feasibility test questionnaire on 24 students. The result showed that Edmodo mobile on CB developed through Thiagarajan 4D has valid criteria. Thus, it can be used in cell biology learning.