Polycystic Ovary Syndrome (PCOS) is an endocrine disorder of uncertain aetiology that affects women of reproductive age, characterized by features of anovulation, irregular menstrual cycle, hirsutism and acne. Although it is the commonest cause for infertility, most women remain unaware until diagnosed. This was a cross-sectional study using quantitative research approach to collect information from preclinical female students in Faculty of Health and Medicine (FMHS), UNIMAS regarding contributing factors such as Body Mass Index (BMI), menstrual cycle, lifestyle patterns and knowledge on PCOS. A total of 201 respondents participated in which 122 of them medical students and 79 were nursing students. One of the main findings of this study was that most of the students were found to be classified under ideal BMI, 12.4% were overweight and 14.9% were underweight. Statistical analysis indicated that there was no difference in the nutritional status of the medical and nursing students. The students were found to be significantly associated with pre-menstrual symptoms (PMS) and their menstrual cycle patterns were found to be significantly irregular due to stress (p<0.05). Majority of the medical and nursing students enjoyed going to the gym during their leisure time (p<0.05). Moreover, both medical and nursing students practiced sedentary activities during leisure time as their mean scores fell below 1.50. The medical students were significantly (p=0.002) more knowledgeable (Mean=0.38; SD=0.20) compared to nursing students (Mean=0.28; SD=0.21). Nevertheless, both groups were considered having poor knowledge on PCOS as their mean score fell below 0.5.