Objectives: While critical value procedures have been adopted in most areas of the clinical laboratory, their use in transfusion medicine has not been reviewed in detail. The results of this study present a comprehensive overview of critical value reporting and communication practices in transfusion medicine in the United States.Methods: A web-based survey was developed to collect data on the prevalence of critical value procedures and practices of communicating results. The survey was distributed via email to US hospital-based blood banks.Results: Of 123 facilities surveyed, 84 (68.3%) blood banks had a critical value procedure. From a panel of 23 common blood bank results, nine results were selected by more than 70% of facilities as either a critical value or requiring rapid communication as defined by an alternate procedure.Conclusions: There was overlap among results communicated by facilities with and without a critical value procedure. The most frequently communicated results, such as incompatible crossmatch for RBC units issued uncrossmatched, delay in finding compatible blood due to a clinically significant antibody, and transfusion reaction evaluation suggestive of a serious adverse event, addressed scenarios associated with the leading reported causes of transfusion-related fatalities.Critical value reporting systems were first described by Lundberg 1 in 1972 to facilitate immediate notification of a responsible physician when test results were at such a variance from normal as to be life threatening without prompt treatment. Critical value reporting was quickly introduced into the clinical laboratory workflow and has become ubiquitous throughout chemistry, hematology, and microbiology. Critical value reporting has since expanded into areas with qualitative or interpretive results such as surgical pathology, cytopathology, and diagnostic imaging. 2,3 Transfusion medicine has been on the frontline of developing quality systems and improving patient safety for decades, but the application of critical valueUpon completion of this activity you will be able to: outline the history of critical values reporting and regulatory requirements for defining and reporting critical values. describe which blood bank results are most frequently communicated, either as a part of a critical values procedure or as part of another procedure. discuss factors that contribute to implementation of critical values in transfusion medicine. summarize the communication of blood bank results, as revealed by the survey.The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit TM per article. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity qualifies as an American Board of Pathology Maintenance of Certification Part II Self-Assessment Module.The authors of this article and th...