Implementation of a multifunctional logic gate based on folding/unfolding transitions of a protein

Deonarine, Andrew S.; Clark, Sonya M.; Konermann, Lars

doi:10.1016/s0167-739x(02)00110-3

Cited by 50 publications

(31 citation statements)

References 47 publications

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“…While proteins have been viewed as logic gates for some time, [58] Konermann now shows that cytochrome c is a logic gate that is reversibly reconfigurable by choosing different input sets. [59] In its native state cytochrome c has quenched fluorescence (output 0), since the tryptophan fluorophore is held close to the heme quencher unit. Chemical denaturants (the inputs) unfold the protein so that the tryptophan fluorophore is able to distance itself from the heme unit and thus emit strongly (output 1).…”

Section: Reconfigurable and Superposed Molecular Logicmentioning

confidence: 99%

Molecular‐Scale Logic Gates

Silva

McClenaghan

2004

Chemistry A European J

599

240

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Currently available approaches to molecular-scale logic gates are summarized and compared. These include: chemically-controlled fluorescent and transmittance-based switches concerned with small molecules, DNA oligonucleotides with fluorescence readout, oligonucleotide reactions with DNA-based catalysts, chemically-gated photochromics, reversibly denaturable proteins, molecular machines with optical and electronic signals, two-photon fluorophores and multichromophoric transient optical switches. The photochemical principles of electron and energy transfer are involved in several of these approaches. More complex molecular logic systems with reconfigurability and superposability provide contrasts with current semiconductor electronics. Integration of simple logic functions to produce more complex ones is also discussed in terms of recent developments.

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Section: Reconfigurable and Superposed Molecular Logicmentioning

confidence: 99%

Molecular‐Scale Logic Gates

Silva

McClenaghan

2004

Chemistry A European J

599

240

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“…Furthermore, the biocatalytic nature of many utilized biomolecular processes, offers certain advantages for analog noise control in the binary-gate circuit design paradigm. [17] Proteins/enzymes [5][6][7][8][9][10][11][12][14][15][16][17][19][20][161][162][163][164][165] and DNA/RNA/DNAzymes [6,7,[166][167][168][169][170][171][172][173][174][175][176][177][178][179][180][181][182] have been extensively used for gates, for realizing small networks and computational units, and for systems motivated [183] by applications.…”

Section: Introductionmentioning

confidence: 99%

Control of Noise in Chemical and Biochemical Information Processing

Privman

2011

Israel Journal of Chemistry

103

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Abstract:We review models and approaches for error-control in order to prevent the buildup of noise when gates for digital chemical and biomolecular computing based on (bio)chemical reaction processes are utilized to realize stable, scalable networks for information processing.Solvable rate-equation models illustrate several recently developed methodologies for gatefunction optimization. We also survey future challenges and possible new research avenues.

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“…Unfolding of the protein separates the heme group from the tryptophan and consequently the tryptophan fluorescence can be detected. This denaturation dependent fluorescence of cytochrome c has been used to implement an AND and an OR logic gate [308]. In the same work an XOR gate was also reported, but it is trivially based on the neutralization of equal amounts of acid and base used as input signals.…”

Section: Conformation-based Computationmentioning

confidence: 99%

Molecular Information Technology

Zauner

2005

Critical Reviews in Solid State and Materials Sciences

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ABSTRACT:Molecular materials are endowed with unique properties of unrivaled potential for high density integration of computing systems. Present applications of molecules range from organic semiconductor materials for low-cost circuits to genetically modified proteins for commercial imaging equipment. To fully realize the potential of molecules in computation, information processing concepts that relinquish narrow prescriptive control over elementary structures and functions are needed, and self-organizing architectures have to be developed. Investigations into qualitatively new concepts of information processing are underway in the areas of reaction-diffusion computing, self-assembly computing, and conformation-based computing. Molecular computing is best considered not as competitor for conventional computing, but as an opportunity for new applications. Microrobotics and bioimmersive computing are among the domains likely to benefit from advances in molecular computing. Progress will depend on both novel computing concepts and innovations in materials. This article reviews current directions in the use of bulk and single molecules for information processing. KEY WORDS:polymer electronics, molecular switches, self-assembly computing, conformation-based computation, self-organizing materials, bioimmersive computing

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Implementation of a multifunctional logic gate based on folding/unfolding transitions of a protein

Cited by 50 publications

References 47 publications

Molecular‐Scale Logic Gates

Molecular‐Scale Logic Gates

Control of Noise in Chemical and Biochemical Information Processing

Molecular Information Technology

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