We here present a new PLC-POWERLINK industrial solution for Industry 4.0 applications. The proposed solution provides the capability to separate the sensing functionality from the PLC-side, in demand for the reconfigurable FPGA implementation. In particular, we here provide a framework that supports the interfacing between the POWERLINK protocol and commonly used standards, such as I2C, SPI, and UART. This has been obtained by using a framework built around a soft IP-core Application Processor, which manages the interfacing with several POWERLINK slaves, able to support the data exchange with the POWERLINK Communication Processor. A practical application example and related implementation details are presented in the paper.