Implementation of a Q fever vaccination program for high-risk patients in the Netherlands

Isken, L; Kraaij-Dirkzwager, Marleen; Bondt, Patricia E. Vermeer-de; Rümke, H. C.; Wijkmans, C.J.; Opstelten, Wim; Timen, Aura

doi:10.1016/j.vaccine.2013.03.062

Cited by 30 publications

(21 citation statements)

References 16 publications

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“…Individuals screened in the Dutch Q fever vaccination campaign from January to April 2011, as previously described, were used as controls . They all had pre‐existing valvular or vascular risk factors for Q fever endocarditis or vascular infection . Control individuals were classified as seronegative if both serological testing and the Q‐vax ® skin test (CSL, Parkville, Australia) were negative ( n = 908).…”

Section: Methodsmentioning

confidence: 99%

A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

Schoffelen

Sprong

Bleeker‐Rovers

et al. 2014

Clinical Microbiology and Infection

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Infection with Coxiella burnetii may lead to life-threatening chronic Q fever endocarditis or vascular infections, which are often difficult to diagnose. The present study aims to investigate whether measurement of in-vitro interferon-gamma (IFN-γ) production, a key cytokine in the immune response against C. burnetii, differentiates chronic from a past cleared infection, and whether measurement of other cytokines would improve the discriminative power. First, C. burnetii-specific IFN-γ production was measured in whole blood of 28 definite chronic Q fever patients and compared with 135 individuals with past Q fever (seropositive controls) and 908 seronegative controls. IFN-γ production was significantly higher in chronic Q fever patients than in controls, but with overlapping values between patients and seropositives. Secondly, the production of a series of other cytokines was measured in a subset of patients and controls, which showed that interleukin (IL)-2 production was significantly lower in patients than in seropositive controls. Subsequently, measuring IL-2 in all patients and all controls with substantial IFN-γ production showed that an IFN-γ/IL-2 ratio >11 had a sensitivity and specificity of 79% and 96%, respectively, to diagnose chronic Q fever. This indicates that a high IFN-γ/IL-2 ratio is highly suggestive for chronic Q fever. In an additional group of 25 individuals with persistent high anti-Coxiella phase I IgG titres without definite chronic infection, all but six showed an IFN-γ/IL-2 ratio <11. In conclusion, these findings hold promise for the often difficult diagnostic work-up of Q fever and the IFN-γ/IL-2 ratio may be used as an additional diagnostic marker.

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Section: Methodsmentioning

confidence: 99%

A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

Schoffelen

Sprong

Bleeker‐Rovers

et al. 2014

Clinical Microbiology and Infection

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“…Efforts to Box 1: Inclusion and exclusion conditions for Q fever vaccination, and coding criteria for adverse events following Q fever skin test and vaccination 2 -hindrance and some interference with normal activity 3 -considerable impediment of normal functioning, need for treatment e -duration 1 -start and resolve within 3 days after vaccination, early 2 -start within 3 days and resolve within 6 days after vaccination, long 3 -start and resolve day 4-6 after vaccination, late 4 -continuation after day 6, extended reach target populations were most intensive in the high-incidence area. GPs identified and referred patients [18].…”

Section: Target Populationmentioning

confidence: 99%

“…In total, 1786 patients (out of 2741 referred) were screened (1118 male; 63%) [18]. Their median age was 67 (range 14-92), similar for both sexes, with 1231 (69%) patients being 60 years and over (male 72%, female 64%).…”

Section: Description Of the Populationmentioning

confidence: 99%

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Adverse events and association with age, sex and immunological parameters of Q fever vaccination in patients at risk for chronic Q fever in the Netherlands 2011

Schoffelen

Wong

Rümke³

et al. 2014

Vaccine

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“…À la suite de ces mesures, les cas de fièvre Q ont diminué aux Pays-Bas. La vaccination de 1368 personnes à risque (maladies vasculaires) a également eu lieu de janvier à juin 2011 après recrutement des patients par leur médecin généraliste (Isken et al 2013). Il reste cependant à surveiller la population humaine pour les cas de fièvre Q chronique .…”

Section: L'épidémie Aux Pays-basunclassified

Coxiella burnetii, agent de la fièvre Q

Boarbi¹,

Frétin²,

Mori³

2016

Can. J. Microbiol.

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Résumé : La fièvre Q est une zoonose de répartition mondiale excepté la Nouvelle-Zélande. Elle est due à une bactérie intracellulaire : Coxiella burnetii. Cette infection passe souvent inaperçue car la manifestation principale de la forme aiguë de la maladie est un syndrome pseudogrippal spontanément résolutif. C'est l'épidémie qui a eu lieu aux Pays-Bas qui a attiré l'attention sur cette maladie qui était moins étudiée auparavant. Cette synthèse résume la description de la bactérie (taxonomie, cycle intracellulaire et génomique) mais également la maladie (description, diagnostic, pathogénie et épidémiologie). Enfin, la vaccination de l'humain et des animaux est également analysée. Mots-clés : Coxiella burnetii, fièvre Q, épidémiologie, description, génomique.Abstract: Q fever is a zoonosis of worldwide distribution with the exception of New Zealand. It is caused by an intracellular bacterium, Coxiella burnetii. The disease often goes underdiagnosed because the main manifestation of its acute form is a general self-limiting flu-like syndrome. The Dutch epidemics renewed attention to this disease, which was less considered before. This review summarizes the description of C. burnetii (taxonomy, intracellular cycle, and genome) and Q fever disease (description, diagnosis, epidemiology, and pathogenesis). Finally, vaccination in humans and animals is also considered.

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Implementation of a Q fever vaccination program for high-risk patients in the Netherlands

Cited by 30 publications

References 16 publications

A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

Adverse events and association with age, sex and immunological parameters of Q fever vaccination in patients at risk for chronic Q fever in the Netherlands 2011

Coxiella burnetii, agent de la fièvre Q

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