evidence" (data derived from a system's own clinical, utilization and expenditure estimates); 8 (4) conduct economic analyses as needed; 7 (5) combine results from the HTA process with stakeholder input to forge standardized guidelines, clinical pathways, and clinical decision support tools that directly bridge evidence and stakeholder values and preferences with clinical practice 2 and last; (6) analyze results of implementation and strategize needed enhancements. 7 Although many US health systems seek evidence to guide acquisition of technology and pharmaceuticals or the implementation of new care delivery models, 8 most do not have the infrastructure to obtain or implement evidence in practice. 7 Health system-based HTA centers fill this void.As an example, University of Pennsylvania Health System established the Center for Evidence-based Practice in 2006 to support health system-based HTA and the integration of evidence into practice. 9 Startup cost and infrastructure were minimal; initial support partially funded two physicianadministrators and a masters-level research analyst. Staffing grew as demand for services grew, to four full-time analysts, one administrative assistant, and two physician faculty codirectors who each dedicated 0.50 full-time equivalents to the effort. At Penn, evidence reviews are generated on topics requested by clinical and administrative leaders. Local patterns of care are analyzed and econometric analyses conducted as needed. The end-products are rapid reviews and cost analyses that put clinical evidence into local context, and ensure that best practices inform care and expenditure decisions. Since 2006, in total, 450 new rapid evidence reviews or economic evaluations have been produced and the Center has disseminated or implemented over 250 clinical pathways and 25 computerized clinical decision support interventions, resulting in improved patient outcomes and the delivery of high-value care. 7 For example, as a result of Penn's healthcare systembased HTA process, the appropriate use of venous thromboembolism prophylaxis has increased 30%. 10 The decision to use chlorhexidine as opposed to iodine for preoperative skin antisepsis was estimated to not only decrease surgical site infections but also to incur cost savings of $500,000 per year 11 -less than the expenditure to initially run the Center for Evidence-based Practice.Another example of health system-based HTA is the Kaiser Permanente Interregional New Technologies Committee, JGIM 1296