Implementation of antimicrobial stewardship to reduce antimicrobial drug resistance

Razzaque, Mohammed S

doi:10.1080/14787210.2021.1840977

Cited by 27 publications

(21 citation statements)

References 24 publications

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“…298 This research expects that in the next five to ten years' time scientific arena and all healthcare stakeholders will have better collaboration and coordination between public and non-governmental organizations of national and international level to promote improved healthcare for all. [347][348][349] Researchers expect one-decade time hopefully, all countries, especially lower-and-middle income countries, will be able to strengthen the healthcare system based on the PHC concept to ensure health-related equity. 307−350−355 Subsequently, our planet may have universal health coverage based on the PHC concept to fight back any future viral pandemic like COVID-19 and improve access and equity healthcare.…”

Section: Primary Health Care In the Management Of The Global Pandemicmentioning

confidence: 99%

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Samad¹,

Sodunke²,

Abubakar³

et al. 2021

JIR

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The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for COVID-19 management. Also, there is an urgent need to discover effective medicines, prevention, and control methods because of the harsh death toll from this novel coronavirus infection. Acute respiratory tract infections, significantly lower respiratory tract infections, and pneumonia are the primary cause of millions of deaths worldwide. The role of micronutrients, including trace elements, boosted the human immune system and was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, and folate; microelement including zinc, iron, selenium, magnesium, and copper; omega-3 fatty acids as eicosapentaenoic acid and docosahexaenoic acid plays essential physiological roles in promoting the immune system. Furthermore, zinc is an indispensable microelement essential for a thorough enzymatic physiological process. It also helps regulate gene-transcription such as DNA replication, RNA transcription, cell division, and cell activation in the human biological system. Subsequently, zinc, together with natural scavenger cells and neutrophils, are also involved in developing cells responsible for regulating nonspecific immunity. The modern food habit often promotes zinc deficiency; as such, quite a few COVID-19 patients presented to hospitals were frequently diagnosed as zinc deficient. Earlier studies documented that zinc deficiency predisposes patients to a viral infection such as herpes simplex, common cold, hepatitis C, severe acute respiratory syndrome coronavirus (SARS-CoV-1), the human immunodeficiency virus (HIV) because of reducing antiviral immunity. This manuscript aimed to discuss the various roles played by zinc in the management of COVID-19 infection.

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Section: Primary Health Care In the Management Of The Global Pandemicmentioning

confidence: 99%

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Samad¹,

Sodunke²,

Abubakar³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…Recent in vitro studies on human airway cell lines have shown that zinc and azithromycin can suppress the expression of ACE2, and the investigators have speculated the potential prophylactic and therapeutic value of this combination for COVID-19 patients [53] . Exacerbation of antimicrobial resistance appears to be another casualty of the COVID-19 pandemic [54] , and implementation of antimicrobial stewardship to reduce antimicrobial drug resistance in this pandemic should be a medical priority [55] , [56] .…”

Section: Zinc: An Antiviral Nutrientmentioning

confidence: 99%

COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?

Razzaque

2021

Computational and Structural Biotechnology Journal

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Coronavirus disease-19 (COVID-19)-induced severe acute respiratory syndrome is a global pandemic. As a preventive measure, human movement is restricted in most of the world. The Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), along with the WHO have laid out some therapeutic guidelines for the infected patients. However, other than handwashing and vigilance surrounding commonly encountered oronasal symptoms and fever, no useful prophylactic measure has yet been established. In a pandemic, the accessibility of a prophylactic biologically active substance is crucial. Ideally, it would be something readily available at a low price to a larger percentage of the population with minimal risk. Studies have demonstrated that zinc may reduce viral replication and increase immune responses. For example, in some studies, zinc supplementation used against the influenza virus has been shown to yield clinical benefits with reduced disease burden. While consuming zinc (within the recommended upper safety limits), as a prophylactic might provide an additional shield against the initiation and progression of COVID-19 would need clinical studies, the potential clearly exists.

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“…The widespread use of antimicrobial drugs during the ongoing COVID-19 pandemic [1, 2,5], and with the likely emergence of antibiotic-resistant microorganisms, there is an urgency for developing novel therapeutic strategies to reduce the burden on existing antimicrobial drugs [23][24][25][26]. In a systematic review of the literature (from January 1, 2020 to April 17, 2020), despite around 7% of hospitalized patients with COVID-19…”

Section: Expert Opinionmentioning

confidence: 99%

Exacerbation of antimicrobial resistance: another casualty of the COVID-19 pandemic?

Razzaque

2020

Expert Review of Anti-infective Therapy

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Implementation of antimicrobial stewardship to reduce antimicrobial drug resistance

Cited by 27 publications

References 24 publications

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?

Exacerbation of antimicrobial resistance: another casualty of the COVID-19 pandemic?

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