The introduction of IT was one of the key priorities for policy-makers in healthcare organisations over the last two decades, due to the potential benefits of this technology to improve healthcare services and quality. However, about 50% of those projects failed to achieve their intended aims. This was as a result of several factors, and included the cost of these projects. The Saudi MoH was planning on implementing EHRS in around 2200 PHCs nationwide. It was acknowledged that this project may face hurdles, which might result in the failure of the project, if implementation facilitators were not first determined. According the Saudi MoH, previous EHRS implementation in the PHCs failed as a consequence of several barriers, such as poor infrastructure, lack of connectivity and lack of interoperability. However, the facilitators to the successful EHRS implementation in the Saudi PHCs not understood. Objective:To determine the facilitators that enhance the success of the implementation of the EHRS in the PHCs in SA.Method:A mixed methods approach was used with both qualitative and quantitative methods (Qualitative using semi-structured interviews and quantitative with a closed survey). The purpose of the utilization of exploratory mixed-methods was to identify a wide range of facilitators that may influence EHRS implementation. The data were obtained from two different perspectives (PHCs practitioners and project team members), 351 practitioners from 21 PHCs participated in the online based, while 14 key informants at the Saudi MoH who were directly involved in the EHRS implementation in the PHCs agreed to be interviewed face to face.Results:The findings from both studies revealed several facilitators. Among these facilitators, financial resources were found to be the most influential factor which assisted in overcoming some barriers such as software selection. The size of the PHCs was the second facilitator to successful implementation. This was despite the scale of the project. The perceived usefulness was another facilitator identified in both the interviews and survey. More than 90% of the participants thought that the EHRS was useful and could contribute to improving the quality of healthcare services. While high level of satisfaction was expressed toward the EHRS usability and efficiency, low levels of satisfaction were recorded toward organisational factors such as user-involvement, training and support. Hence, the system usability and efficiency were documented to be other facilitators of successful EHRS implementation in the Saudi PHCs Conclusion: The findings of the present study suggest that sufficient financial support is essential to enhance the success of the EHRS implementation, despite the scale of the project. Also, effective leadership and project management were found core factors to overcome many obstacles and thus ensure the success of large-scale projects