The article discusses the theoretical issues of the application of innovative social technologies in the general mechanism of managing the region as a separate territorial unit. The mechanisms of using social technologies to achieve a managerial effect are considered, and critical tools for making a given social result are identified. From the point of view of the methodology, a comprehensive algorithm for the application of social technologies in the general strategy for managing the region is proposed. A sequence of stages of social interaction is presented, during which the management strategy is implemented and forms social reality. Social technologies are considered from the position of a key tool of the management system, and also the effects exerted on all spheres of society are examined. The relationship between the effectiveness of applying social technology and the effectiveness of the resulting vector of managerial impact, between conditional social costs and potential incomes, is separately highlighted.