4How to use efficient energy in wireless sensor networks (WSN) is one of the major challenges due to limited energy batteries and computation capacity. Therefore, in this paper, we propose combining a chain-base routing scheme and data fusion sensor information (CRSDF for short). CRSDF contains two major works: Firstly, the chain-based routing method is applied to connect sensor nodes into a chain in which each node transmits only with the nearest neighbor using the remaining energy and distance of nodes as standard parameters to determine which node will be selected the chain leader, secondly, we fuse and compress one or more data packets to generate a result packet with small size base on the Slepian-Wolf and Dempster-Shafer theory. The simulation results exhibit that the energy efficiency of our proposed protocol can be improved by 40%, 20%, and 15% compared to low-energy adaptive clustering hierarchy (LEACH), power-efficient gathering in sensor information system (PEGASIS), and an improved energy-efficient PEGASIS-Based protocol, respectively. Index Terms4Energy-efficient, routing protocol, chainbased clustering, wireless sensor networks, data fusion.