Implementation of Newborn Screening for Hemoglobin H Disease in Mainland China

Xie, Xing-Mei; Zhang, Jianying; Li, Jian; Li, Ru; Liao, Can; Li, Dong-Zhi

doi:10.1007/s12288-014-0432-y

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Shallow geothermal energy is often tapped in the form of hot water or steam (e.g. hydrothermal production), while deep geothermal energy often takes the form of "hot dry rock" resources that usually exists at depths greater than 3-5 km beneath the Earth's surface (Rubio-Maya et al, 2015;Xie et al, 2020). China has enormous geothermal resource potential, however, low-temperature geothermal resources are more common than high-temperature ones.…”

Section: Introductionmentioning

confidence: 99%

High-resolution ambient noise imaging of geothermal reservoir using 3C dense seismic nodal array and ultra-short observation

Cheng

Xia

Ajo‐Franklin

et al. 2021

Preprint

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Tomographic imaging based on long-term ambient seismic noise measurements, mainly the phase information from surface waves, has been shown to be a powerful tool for geothermal reservoir imaging and monitoring. In this study, we utilize seismic noise data from a dense nodal array (192 3C nodes within 20km2) over a ultra-short observation period (4.7 days) to reconstruct surface waves and determine the high-resolution (0.2km) three-dimensional (3-D) S wave velocity structure beneath a rural town in Zhejiang, China. We report the advantage of cross-coherence over cross-correlation in suppressing pseudo-arrivals caused by persistent sources. We use ambient noise interferometry to retrieve high quality Rayleigh waves and Love waves. Body waves are also observed on the R-R component interferograms. We apply phase velocity dispersion measurements on both Rayleigh waves and Love waves and automatically pick more than 23,000 dispersion curves by using a Machine Learning technique. 3-D surface wave tomographic results after depth inversion indicate low-velocity anomalies (between -1% and -4%) from the surface to 2km depth in the central area. Combined with the conductive characteristics observed on resistivity profile, the low-velocity anomalies are inferred to be a fluid saturated zone of highly fractured rock. Joint interpretation based on HVSR measurements, and existing temperature and fluid resistivity records observed in a nearby well, suggests the existence of the high-temperature geothermal field through the fracture channel. Strong correlation between HVSR measurements and S wave velocity model sheds light on the potential of extraction of both amplitude and phase information from ambient noise.

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Section: Introductionmentioning

confidence: 99%

High-resolution ambient noise imaging of geothermal reservoir using 3C dense seismic nodal array and ultra-short observation

Cheng

Xia

Ajo‐Franklin

et al. 2021

Preprint

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Thalassaemia screening and confirmation of carriers in parents

Barrett

Ramasamy

Choolani

2017

Best Practice & Research Clinical Obstetrics & Gynaecol

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Pre Gestational Thalassemia Screening in Mainland China: The First Two Years of a Preventive Program

Jiang

Chen

et al. 2017

Hemoglobin

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In this study, we report the experience of a pre gestational thalassemia screening program at a single center in Southern China. Free thalassemia screening, genetic counseling and prenatal diagnosis (PND) for couples planning pregnancy were implemented over a 2-year period. Among a total of 83,062 screened individuals (41,531 couples), the allele frequencies of β-thalassemia (β-thal), - - and - - deletions were 3.79, 5.75 and 0.028%, respectively. Out of the 41,531 couples, 11,039 couples had at least one partner who had a positive screening test; of these, 455 at-risk couples (1.07%) were identified, including 68 (0.16%) for β-thal, 162 (0.39%) for Hb Bart's (γ4) hydrops fetalis, 190 (0.46%) for deletional Hb H (β4) disease and 25 (0.06%) for nondeletional Hb H disease. Of the 455 at-risk couples, 90 were already pregnant and 66 underwent PND at 10-13 weeks' gestation, resulting in 15 affected fetuses. The remaining 355 at-risk couples were still preparing for pregnancy, and they were on the list for follow-up. There is considerable scope for facilitating timely PND through improved organization and screening strategy. The pre pregnancy screening is a feasible and effective approach to thalassemia prevention.

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Implementation of Newborn Screening for Hemoglobin H Disease in Mainland China

Abstract: Hemoglobin H disease is the most severe non-

Cited by 3 publications

References 22 publications

High-resolution ambient noise imaging of geothermal reservoir using 3C dense seismic nodal array and ultra-short observation

High-resolution ambient noise imaging of geothermal reservoir using 3C dense seismic nodal array and ultra-short observation

Thalassaemia screening and confirmation of carriers in parents

Pre Gestational Thalassemia Screening in Mainland China: The First Two Years of a Preventive Program

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