Background: Patient safety is a framework of organized activities that creates cultures, processes, procedures, behaviors, technologies, and environments in health care that consistently and sustainably: lower risks, reduce the occurrence of avoidable harm, make errors less likely and reduce its impact when it does occur. Nurses have tragedy a censoriously vital role in confirming patient safety whereas as long as give care directly to patients. This study aimed to evaluate the effectiveness of in-service training program on nurses' performance regarding patient safety practices standards in intensive care units. Design: A quasi-experimental research design was utilized. Setting: The study was conducted at the main intensive care unit at the surgical building affiliated with Ain Shams University Hospital (El-Demerdash). Subject: A purposive sample of comprised of 65 staff nurses was working in previous mentioned setting. Tools: (I) A structured interviewing questionnaire; it covered demographic characteristics of nurses and interview knowledge questionnaire, (II) Nurses' practical observational checklist. Results: There were improvements in the studied nurses' satisfactory level of knowledge and competent level of practice throughout pre/post and follow up phases, with a highly statistically significant difference between pre/post at (P < 0.003). There was statically highly significant relation between total level of studied nurses' knowledge and practice for pre/post and follow-up at P > 0.000.
Conclusion:The nurses' knowledge and practice regarding patient safety practice standards in intensive care units have been effectively improved throughout pre/post and follow-up phases of an in-service training program implementation. Recommendation: Designing a written educational programs and implementation of regular updating of nurses' knowledge and practices concerning patient safety practices standards in intensive care units.