The aim of this work was to evaluate the use of Municipal Solid Wastes (RSU) to mitigate the CO 2 equivalent (CO 2 eq) through the proposal to implement a landfill to produce biogas and use it as a substitute fuel. This proposal is made for the Lerma-Chapala region in the Mexican state of Michoacan de Ocampo, which consists of 17 municipalities at the Norwest of the State. Biogas production was estimated with the Biogas Mexican Model version 2.0. The energy fuels that could be substituted are: alcohol, gasoline, gas oil, natural gas, coal, diesel, LP gas, wood, barrels of oil equivalent (BEP) and electric power. The estimation was for a 21 years period considering the useful life of the landfill. Five fuel energy sources were finally considered as substitutes: oil, diesel, LP gas, BEP and electric power, contrasting the gross saving with total costs of the landfill. The best output was when gasoline was substituted. On the other hand, 890,361 ton of de CO 2 eq could be avoided by direct burning of biogas and 147,456 ton of CO 2 by not burning fossil fuels to generate electricity.