A modern cytopathology laboratory is offering various examinations with vital clinical significance. The wide application of computers and information systems successfully operates in modern cytopathology laboratories. Over the last decade, clinical cytopathology has been influenced by the broad implementation of telemedicine and cloud-based applications. New innovative information technologies, including e-health and telemedical applications, constitute a valuable tool for interlaboratory collaboration and quality improvement. New applications, especially in cloud computing, have enhanced the opportunities for improvement in cytological data management and sharing. In this chapter, the author presents a thorough research of telemedical and cloud-based applications related to cytopathology and tries to foresee applications that may improve cytopathology laboratories' diagnostic services relating to population health management, pharmacogenomics and patient-centered care.