2020
DOI: 10.1007/s12247-020-09524-3
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Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled Impeller Speed of the Granulation Unit, Compaction Force and Gap Width

Abstract: Purpose In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In order to manufacture solid oral dosage forms continuously, valid control strategies for critical quality attributes should be established. To this date, there are no published control strategies for granule size distribution in continuous dry granulation. Methods In-line laser diffraction was used to dete… Show more

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Cited by 6 publications
(1 citation statement)
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“…Therefore, it is urgent to develop an active in-line control method to ensure the weight uniformity of dripping pills. Feedback control strategy provides an important approach to improve the reliability of pharmaceutical production processes in continuous manufacturing of pharmaceuticals [8][9][10] .…”
Section: Real-time Quality Control Of Dripping Pill's Weight Based On...mentioning
confidence: 99%
“…Therefore, it is urgent to develop an active in-line control method to ensure the weight uniformity of dripping pills. Feedback control strategy provides an important approach to improve the reliability of pharmaceutical production processes in continuous manufacturing of pharmaceuticals [8][9][10] .…”
Section: Real-time Quality Control Of Dripping Pill's Weight Based On...mentioning
confidence: 99%