“…Its management can be challenging due to disease factors and co-morbidity. In addition there are a number of unique geographical, cultural, socioeconomic and service/support related factors that mean that many remote, and the majority of Indigenous patients in the NT, do not achieve the clinical targets and improved outcomes seen in randomised controlled trials (RCT) and large centre prospective studies [1][2][3][4]. Although there have been many advancements in the management of CHF, the extent to which the results of RCTs and the 'evidence-based' guidelines generated from them are applicable outside of the trial setting (known as relevance, effectiveness or external validity) [5,6], and in particular to Indigenous patients in the NT, is problematic.…”