Implementing Personalized Medicine in a Cancer Center

Abstract

In 2006, the Moffitt Cancer Center partnered with patients, community clinicians, industry, academia, and seventeen hospitals in the United States to begin a personalized cancer care initiative called Total Cancer Care™ . Total Cancer Care was designed to collect tumor specimens and clinical data throughout a patient’s lifetime with the goal of finding “the right treatment, for the right patient, at the right time.” Because Total Cancer Care is a partnership with the patient and involves collection of clinical data and tumor specimens for research purposes, a formal protocol and patient consent process was developed and an information technology platform was constructed to provide a robust “warehouse” for clinical and molecular profiling data. To date, over 76,000 cancer patients from Moffitt and consortium medical centers have been enrolled in the protocol. The TCC initiative has developed many of the capabilities and resources that are building the foundation of personalized medicine.

Adaptive Responses to Dasatinib-Treated Lung Squamous Cell Cancer Cells Harboring DDR2 Mutations

“…Tumor tissues were collected as part of the Total Cancer Care™ protocol (22), and approved by the University of South Florida IRB. Patients gave informed written consent before enrollment in the Total Cancer Care protocol.…”

Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer

“…The Total Cancer Care (TCC) initiative includes a comprehensive patient database and tissue bank from 17 cancer centers around the nation [12]. In order to assess whether RSI is predictive in patients with resectable pancreatic cancer treated with radiation, we used the TCC to identify patient, tumor, and treatment characteristics for all patients treated with resectable pancreatic cancer.…”

Problems, challenges and promises: perspectives on precision medicine

“…Oncology is the medical field most rapidly adopting genomic-era medicine, with most major cancer centres developing personalised medicine initiatives [6,12,[60][61][62][63][64][65]. As such, oncology also appears poised to be the pioneer of precision medicine approaches as it seeks to interpret ever growing datasets for individual patients.…”