Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation

Chen, Ling‐Wei; Xu, Jia; Soh, Shu E; Aris, Izzuddin M.; Tint, Mya Thway; Gluckman, Peter D.; Tan, Kok Hian; Shek, Lynette Pei‐Chi; Chong, Yap‐Seng; Yap, Fabian; Godfrey, Keith M.; Gilbert, Jack A.; Karnani, Neerja; Lee, Yung Seng

doi:10.1038/s41366-020-0572-0

Cited by 47 publications

(53 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Across an number of studies, a consistent association has been found between antibiotic-induced changes in the gut microbiota and either childhood adiposity or obesity [ 121 , 122 , 123 , 124 , 125 ]. Zhang and colleagues investigated the influence that prenatal antibiotic exposure had on infant weight for length score (WFL-score), adiposity, and alterations in the gut microbiota [ 121 ].…”

Section: Human Studies Linking Early-life Antibiotic Exposure To Omentioning

confidence: 99%

“…Chen et al examined the effect of antibiotic use in the first year of life in a mother-offspring cohort from Singapore and found that antibiotic treatment was associated with altered gut microbiota composition, increased adiposity, and elevated risk of childhood obesity [ 122 ]. Stool samples collected at 24 months of age showed that repeated antibiotic use reduced the microbial co-abundant group (CAG) represented by Eubacterium hallii , which was negatively correlated with childhood adiposity.…”

Section: Human Studies Linking Early-life Antibiotic Exposure To Omentioning

confidence: 99%

“…The CAGs represented by Tyzzerella 4 and Gemella was also amplified and was positively correlated with childhood adiposity. Any exposure to antibiotic in the first year was associated with a higher odds of obesity from 15 to 60 months of age (OR(95% CI) = 1.45(1.001, 2.14)) [ 122 ].…”

Section: Human Studies Linking Early-life Antibiotic Exposure To Omentioning

confidence: 99%

See 2 more Smart Citations

Obesity, Early Life Gut Microbiota, and Antibiotics

Wilkins

Reimer

2021

Microorganisms

View full text Add to dashboard Cite

Obesity is a major public health problem that continues to be one of the leading risk factors for premature death. Early life is a critical period of time when the gut microbiota and host metabolism are developing in tandem and significantly contribute to long-term health outcomes. Dysbiosis of the gut microbiota, particularly in early life, can have detrimental effects on host health and increase the susceptibility of developing obesity later in life. Antibiotics are an essential lifesaving treatment; however, their use in early life may not be without risk. Antibiotics are a leading cause of intestinal dysbiosis, and early life administration is associated with obesity risk. The following review explores the relevant literature that simultaneously examines antibiotic-induced dysbiosis and obesity risk. Current evidence suggests that disruptions to the composition and maturation of the gut microbiota caused by antibiotic use in early life are a key mechanism linking the association between antibiotics and obesity. Without compromising clinical practice, increased consideration of the long-term adverse effects of antibiotic treatment on host health, particularly when used in early life is warranted. Novel adjunct interventions should be investigated (e.g., prebiotics) to help mitigate metabolic risk when antibiotic treatment is clinically necessary.

show abstract

Section: Human Studies Linking Early-life Antibiotic Exposure To Omentioning

confidence: 99%

Section: Human Studies Linking Early-life Antibiotic Exposure To Omentioning

confidence: 99%

See 1 more Smart Citation

Obesity, Early Life Gut Microbiota, and Antibiotics

Wilkins

Reimer

2021

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Detailed informations indicated that gut microbiota is actually related to plasma levels of Se in mice [29]. In this study, Eubacterium_hallii_group had a positive relationship with Se content in the ileum, and it was a member of the butyrate-producers [75][76][77] allowing it to metabolizes glycerol into reuterin [75][76][77]. Stenotrophomonas, an opportunistic pathogen, had a negative relationship with Se content in ileum.…”

Section: Discussionmentioning

confidence: 57%

Selenium yeast modulated ileal transcriptome and microbiota to ameliorate egg production in aged laying hens

Liu

Cao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The declines in both laying performance and egg shell quality during late production period have adverse effects on long production cycle. Improving nutrition of laying hens is a crucial measure to reverse the declination. Selenium (Se) plays important roles in antioxidant defense, redox balance, immune response, and modulation of gut microbiota. However, the mechanism underlying selenium yeast regulating the interaction between transcriptome and gut microbiota to influence laying performance, is still unclear. Here, we use the transcriptome and 16S rRNA analysis to investigate how selenium yeast alters the gene expression and microbiota composition of ileum in aged laying hens.Results: In this study, selenium yeast ameliorated the depression in aged laying performance with a significant increase of laying rate in 0.30 mg/kg group. Furthermore, functional enrichment and STEM analysis were performed using RNA-Seq, which indicated selenium yeast activated metabolic progresses (e.g. Glycerolipid metabolism, Glycerophospholipid metabolism, and fatty acid metabolism), immune response and oxidative stress response. Four hub genes (TXNRD1, DLD, ILK and LZTS2) were involved in intestinal metabolism which was closely associated with Se deposition/status. Additionally, Se increased the abundance of beneficial bacteria including Veillonella, Turicibacter, and Lactobacillus whiledecreasing the abundance of pathogenic bacteria Stenotrophomonas by 16S rRNA-Seq. The Integrated analysis of omics revealed that several microbiotas (Maritalea, Alteromonas, Geobacter, etc.) were positively associated with both Se content and laying rate, and there was a markable correlation between several specific microbiotas (Aliivibrio, Anaerobacillus, Shewanella, etc.) and the immune response pathways (regulation of acute inflammatory response, positive regulation of lymphocyte activation and IFN gamma response). Meanwhile, the “switched on” gene PSCA had a positive relationship with Veillonella, and a negative relationship with the opportunistic pathogens Stenotrophomonas. CCA analysis indicated that both the Se content and the laying rate were highly positively correlated with Anaerobacillus, Alteromonas, Loktanella and the positive regulation of lymphocyte activation, but were negative correlated with Streptococcus, Devosia, Aerococcus, Intestinibacter and fatty acid metabolic progress. Conclusions: Overall, our study provides unprecedented insights showing that selenium yeast supplementation can affect immune response, metabolic processes, and specific microbiota composition to ameliorate the egg production deterioration in aged laying hens.

show abstract

“…3 These early-life antibiotic exposure could disrupt the gut microbiota, alter the metabolic profile and lead to a higher risk of obesity in later life. 14 Apart from the disease biology, these studies also have important implications on health policies at a population level. As most CRC screening programmes (including that in Singapore) start at the age of 50, these youngonset cancers will be invariably missed.…”

mentioning

confidence: 99%