Implication of inflammation on Coxsackie virus and Adenovirus receptor expression on cardiomyocytes and the role of platelets in patients with dilated cardiomyopathy

Gupalo, Elena; Buryachkovskaya, L. I.; Chumachenko, P.; Миронова, Н. А.; Narusov, Oleg Yu; Tereschenko, S N; Golitsyn, Sergei P; Othman, Maha

doi:10.1016/j.carpath.2022.107452

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…CAR is ubiquitously expressed in tight junctions in epithelial tissues, which are important barriers to prevent the free diffusion of solvents and proteins between the endothelial and epithelial cell layers. The expression of CAR is related to IL-6 ( 11 , 12 ). Recent research has found that CAR leads to the development of cardiac inflammation independent of viral infection itself through inflammatory mitogen-activated protein kinase (MAPK) cascade signaling ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Assistance of metagenomics next-generation sequencing for diagnosis of adenovirus pericarditis with pericardial effusion in a child: a case report and literature review

Lin

Zhang

2023

Front. Pediatr.

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Human adenoviruses (HAdVs) can cause infection at any age but are most common in the pediatric population, especially young children and infants, with a peak incidence in infants and children from 6 months to 5 years of age. Adenovirus infection can cause severe pneumonia, but pericarditis from adenovirus infection was rare. This article reports a case of a 2-year-old patient with pericarditis caused by adenovirus infection and a moderate pericardial effusion. We detected positive adenovirus nucleic acid in the patient’s blood by polymerase chain reaction assay. In addition, HAdVs were identified by metagenomics next-generation sequencing (mNGS) in blood and pericardial effusion. According to the test results and clinical practice, active symptomatic and supportive treatment was given, and finally the child recovered and was discharged from the hospital. Comprehensive and accurate diagnosis of pathogens is a prerequisite for effective treatment, and mNGS provides an effective means for diagnosing rare adenovirus myocarditis in children.

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Section: Discussionmentioning

confidence: 99%

Assistance of metagenomics next-generation sequencing for diagnosis of adenovirus pericarditis with pericardial effusion in a child: a case report and literature review

Lin

Zhang

2023

Front. Pediatr.

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“…The expression level of CXADR in cardiomyocytes and platelets with virus persistence is highly correlated to the expression level of inflammatory cytokines and the degree of inflammatory dilated cardiomyopathy [ 58 ]. CXADR-positive endomyocardial patients express a significantly higher level of tumor necrosis factor α (TNFα) and interleukin 6 (IL-6) in the serum compared with CXADR-negative patients and healthy subjects [ 58 ]. This report sheds light on the relationship between inflammation and CXADR.…”

Section: Pathogeneses Associated With Cxadr Dysregulationmentioning

confidence: 99%

“…Apart from the testis, CXADR exhibits various functions in different organs. Studies have reported that physiological abnormalities such as cardiac failure, impairment in spermatogenesis, and tumour development are related to altered CXADR levels [ 47 , 50 , 58 , 63 ]. It is apparent that proper expression of CXADR in various organs is crucial for normal body function.…”

Section: Regulation Of Cxadrmentioning

confidence: 99%

CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis

Zhang

Lui

2023

IJMS

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Canonical coxsackievirus and adenovirus receptor (CXADR) is a transmembrane component of cell junctions that is crucial for cardiac and testicular functions via its homophilic and heterophilic interaction. CXADR is expressed in both Sertoli cells and germ cells and is localized mainly at the interface between Sertoli-Sertoli cells and Sertoli-germ cells. Knockout of CXADR in mouse Sertoli cells specifically impairs male reproductive functions, including a compromised blood-testis barrier, apoptosis of germ cells, and premature loss of spermatids. Apart from serving as an important component for cell junctions, recent progress has showed the potential roles of CXADR as a signaling mediator in spermatogenesis. This review summarizes current research progress related to the regulation and role of CXADR in spermatogenesis as well as in pathological conditions. We hope this review provides some future directions and a blueprint to promote the further study on the roles of CXADR.

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Viral coagulation: pushing the envelope

George Pryzdial,

Perrier,

Rashid

et al. 2024

Journal of Thrombosis and Haemostasis

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Implication of inflammation on Coxsackie virus and Adenovirus receptor expression on cardiomyocytes and the role of platelets in patients with dilated cardiomyopathy

Cited by 6 publications

References 31 publications

Assistance of metagenomics next-generation sequencing for diagnosis of adenovirus pericarditis with pericardial effusion in a child: a case report and literature review

Assistance of metagenomics next-generation sequencing for diagnosis of adenovirus pericarditis with pericardial effusion in a child: a case report and literature review

CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis

Viral coagulation: pushing the envelope

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