Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study

Bae

et al. 2020

JCM

Hypertension and dyslipidemia often occur as comorbidities, with both being strong risk factors for developing cardiovascular diseases (CVD). Abnormal liver function test could reflect a potential CVD risk even in patients with mild dyslipidemia. The aim of this study was to assess the compounding relationship between liver enzymes and cardiovascular risk factors in subjects with mild dyslipidemia. The present analysis was performed among 438 participants who had enrolled in at least one of the nine clinical studies done at the Chonbuk National University Hospital between 2009 and 2019. Significant linear increasing trends were observed in blood pressure level and other cardiovascular risk factors across quartiles of serum γ-glutamyltransferase (GGT) or alanine aminotransferase (ALT), with the increment in hypertension prevalence occurring across the quartiles of GGT and ALT. On multivariate logistic regression analyses, the odds ratios for hypertension, adjusted for smoking, drinking and obesity, in the highest quartiles of GGT, ALT, aspartate aminotransferase, and alkaline phosphatase were 3.688, 1.617, 1.372, and 1.166, respectively. Our study indicates that GGT is a superior marker for predicting CVD risk among liver enzymes. Routine screening of plasma GGT levels in patients with mild dyslipidemia will allow for early detection of CVD.

Section: Discussionsupporting

confidence: 92%

The Associations between Liver Enzymes and Cardiovascular Risk Factors in Adults with Mild Dyslipidemia

Bae

et al. 2020

JCM

“…Furthermore, increased ALT, GGT and ALP, which were closely associated with liver fat deposition, were considered as indices of liver injury [14][15][16][17]. As mentioned earlier, ALT can serve as an index of hepatocyte death and an indirect maker of liver injury [15,18].…”

Section: Discussionmentioning

confidence: 96%

The relationship between 25-hydroxyvitamin D concentration and liver enzymes in healthy adults: A Cross-sectional Study

Wang

et al. 2020

Preprint

Background Studies have shown that serum 25-hydroxyvitamin D (25(OH)D), a product of exogenous vitamin D, plays an influential role in calcium and phosphorus balance, anti-inflammation, and cardiovascular protection. There were long-standing interests in the potential benefits of vitamin D for preventing liver diseases. Investigations showed that 25(OH)D was increased in adolescents with abnormal liver function. Yet data about the relationship of 25(OH)D concentration and liver enzymes from prospective cross-sectional study was limited. The present study is undertaken to examine whether serum 25-hydroxyvitamin D and glutamyl transferase (GGT), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were closely related. Methods The cross-sectional study of 368 healthy volunteers with no history of liver diseases was used to examine risk factors. Pearson correlation (or Spearman correlation for skewed variables) was performed to assess associations between GGT, ALT, and ALP and 25(OH)D. Linear regression analysis was conducted with GGT, ALT, and ALP as dependent variables in separate models. Results The results found no significant difference between ALT and ALP in different vitamin D groups (25(OH)D < 25 nmol/L、25-50 nmol/L and > 50 nmol/L) (Kruskal-Wallis test, all p > 0.05). In multiple linear regression analysis, GGT, ALT and ALP levels remained unrelated to 25(OH)D concentration after adjusting covariates including age, BMI, sex, BuN, Cr, UA, AST, Ghb, ALB, WBC, cholesterol, HDL, LDL, cholesterol, and total protein. (All p > 0.1). Conclusion This study suggested that there was no association between the 25(OH)D concentration and the levels of GGT, ALT or ALP in normal population.

“…[13]. Furthermore, the elevation of ALT, GGT and ALP were closely related to liver fat deposition and were considered to be an indicator of liver injury [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

The relationship between 25-hydroxyvitamin D concentration and liver enzymes in healthy adults: A Cross-sectional Study

Wang

et al. 2020

Preprint

Background: Studies have shown that serum 25-hydroxyvitamin D (25(OH)D), a product of exogenous vitamin D, plays an influential role in calcium and phosphorus balance, anti-inflammation, and cardiovascular protection. There were long-standing interests in the potential benefits of vitamin D for preventing liver diseases. Investigations showed that 25(OH)D was increased in adolescents with abnormal liver function. Yet data about the relationship of 25(OH)D concentration and liver enzymes from prospective cross-sectional study was limited. The present study is undertaken to examine whether serum 25-hydroxyvitamin D and alanine aminotransferase (ALT) ，glutamyl transferase (GGT) and alkaline phosphatase (ALP) were closely related. Methods: The cross-sectional study of 368 healthy volunteers with no history of liver diseases was used to examine risk factors. The associations between ALT, G and ALP and 25(OH)D were assessed by Pearson correlation and Spearman correlation, respectively. Linear regression analysis was carried out in different models with ALT, GGT and ALP as dependent variables. Results: The results found no significant difference between ALT and ALP in different vitamin D groups (25(OH)D < 25 nmol/L、25-50 nmol/L and > 50 nmol/L) ( Kruskal-Wallis test, all p > 0.05 ). Multiple linear regression analysis revealed that there were no significant association between ALT, GGT and ALP levels and 25(OH)D concentration, respectively, after adjusting covariates including age, BMI, sex, BuN, Cr, UA, AST, Ghb, ALB, WBC, cholesterol, HDL, LDL, cholesterol, and total protein. (All p > 0.1). Conclusion: This study suggested that there was no association between the 25(OH)D concentration and the levels of ALT, GGT or ALP in normal population.