Implication of NMDA-NO pathway in the antidepressant-like effect of ellagic acid in male mice

Lorigooini, Zahra; Salimi, Negin; Soltani, Amin; Amini-Khoei, Hossein

doi:10.1016/j.npep.2019.04.003

Cited by 32 publications

(33 citation statements)

References 58 publications

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“…Forced swimming test (FST) was performed to measure despair behavior in mice reflecting the depressive-like behavior appears as increased immobility time [30]. Animals were discretely located in an open glass cylinder (diameter: 10 cm, height: 25 cm) filled with 19 cm water (23 ± 1 ° C).…”

Section: Behavioral Experiments Forced Swimming Testmentioning

confidence: 99%

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

et al. 2019

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Depression and anxiety are common psychiatric disorders accounting for social and economic burdens. Previous studies have shown that oxidative stress and oxidant/antioxidant imbalance are involved in the pathophysiology of psychiatric disorders. Experiencing early-life adversities (like maternal separation [MS] stress) provoked psychiatric disorders. Trigonelline (TRG) is a pyridine alkaloid that has various pharmacological effects including hypoglycemic, neuroprotective and memory-improving properties. To investigate the antidepressant-and anxiolytic-like effects of TRG focusing oxidative stress, we applied the MS paradigm to male mice at postnatal day (PND) 2-14 (3 h daily, 9-12 a.m.) and investigated the behaviors at PND 45-47. Using valid behavioral tests including a forced swimming test (FST), splash test, open field test (OFT) and elevated plus maze (EPM), we investigated behavioral modifications. Additionally, we examined the effects of MS and TRG treatment on the level of malondialdehyde (MDA), nitric oxide (NO) and also antioxidant capacity in the brain and serum. Our results showed that MS provoked depressive-and anxiety-like behaviors in the FST, OFT, EPM and splash test, which are associated with an increase in MDA and NO levels as well as a decrease in antioxidant capacity in the brain and serum samples. Findings determined that TRG significantly reversed the negative effects of MS on behavior that is accompanied by a decrease in MDA and NO as well as an increase in antioxidant capacity. Findings of the present study showed that beneficial effects of TRG may be, at least partially, mediated via the reduction of oxidative stress and an increase of antioxidant capacity.

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Section: Behavioral Experiments Forced Swimming Testmentioning

confidence: 99%

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

et al. 2019

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“…Indeed, polymorphism of nNOS gene has been reported to increase the susceptibility to schizophrenia (Shinkai, Ohmori, Hori, & Nakamura, ) as well as depression (de Oliveira et al, ). Emerging evidence has shown that upsurge of NO is connected with increase glutamate release and activation of N‐methyl‐ d ‐aspartate (NMDA) receptors (Haj‐Mirzaian et al, ; Lorigooini et al, ). Of note, NO‐mediated glutamate outburst has been reported to cause neuroadaptative hypofunctionality of NMDA receptors (Sorce et al, ), a pathological mechanism that is involved in the preclinical and clinical neurobiology of depression (Lorigooini et al, ; Pittenger, Sanacora, & Krystal, ).…”

Section: Introductionmentioning

confidence: 99%

“…It is rapidly synthesized from L-arginine by nitric oxide synthase (NOS), an enzyme group consisting of three subtypes including inducible (iNOS), endothelia NOS (eNOS) and neuronal NOS (nNOS) (Haj-Mirzaian et al, 2016;Zhang et al, 2013). Behavioral abnormalities associated with high levels of NO have been widely reported in literature (Haj-Mirzaian et al, 2016Harkin, Connor, Burns, & Kelly, 2004;Lorigooini, Salimi, Soltani, & Amini-Khoei, 2019;Ulak et al, 2008;Volke, Wegener, Bourin, & Vasar, 2003). Previous studies have established that NO is involved in several disease conditions characterized of oxidative stress and inflammation, and thus contributes significantly to the associated behavioral impairments (Chatterjee et al, 2012;Haj-Mirzaian et al, 2016.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have established that NO is involved in several disease conditions characterized of oxidative stress and inflammation, and thus contributes significantly to the associated behavioral impairments (Chatterjee et al, 2012;Haj-Mirzaian et al, 2016. L-Arginine, the precursor substrate responsible for the synthesis of NO, has been reported to produce depressive-like behaviors, which were abolished by nitric oxide synthase inhibitors (Ergun & Ergun, 2007;Haj-Mirzaian et al, 2018;Lorigooini et al, 2019). Moreover, 1-(2-trifluoromethylphenyl)imidazile, a novel selective neuronal NOS (nNOS) inhibitor enhances 5-hydroxytryptaminergic (5-HT) neurotransmissions of antidepressants in the FST (Ulak et al, 2008;Volke et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Emerging evidence has shown that upsurge of NO is connected with increase glutamate release and activation of N-methyl-Daspartate (NMDA) receptors (Haj-Mirzaian et al, 2016;Lorigooini et al, 2019). Of note, NO-mediated glutamate outburst has been reported to cause neuroadaptative hypofunctionality of NMDA receptors (Sorce et al, 2010), a pathological mechanism that is involved in the preclinical and clinical neurobiology of depression (Lorigooini et al, 2019;Pittenger, Sanacora, & Krystal, 2007). Although different faces of NO activity have been documented in literature in the pathogenesis of these diseases (Bernstein et al, 2005;Haj-Mirzaian et al, 2018), the psychopharmacological and beneficial effects of selective and nonselective NOS inhibitors in mice submitted to the forced swim test have been well documented (Dhir & Kulkarni, 2011;Lorigooini et al, 2019;Ulak et al, 2008;Zhang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of l‐arginine‐nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice

Ben‐Azu

Aderibigbe

Ajayi

et al. 2019

Drug Development Research

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l‐Arginine‐nitric oxide pathway has been reported to be involved in the mediation of the psychopharmacological effects of many psychotropic drugs. Previous studies have shown that morin, a psychotropic compound isolated from mulberry leaf produces functional psychopharmacological effects indicative of antidepressant, antipsychotic, anxiolytic and nootropic properties. However, the role of l‐arginine‐nitric oxide pathway in the psychotropic effects of morin has not been fully investigated, hence, the need for this study. Male Swiss mice were pretreated individually or in combination with nitric oxide precursor [l‐arginine (750 mg/kg, i.p.)], competitive nonselective nitric oxide synthase (NOS) inhibitor [N(G)‐nitro‐l‐arginine methyl ester (l‐NAME, i.p) (50 mg/kg)] or selective neuronal NOS inhibitor [methylene blue (3.75 mg/kg, i.p)] prior to morin (100 mg/kg, i.p.) or saline (10 mL/kg, i.p.) treatment. Psychopharmacological activities were then evaluated 30 min later using open field, Y‐maze, and forced swim tests. l‐Arginine significantly reversed the effects of morin on locomotion, memory and depression in mice. The reduced motor activity and enhanced memory function produced by morin were significantly attenuated by methylene blue but augmented the antimobility activity of morin in the FST. Moreover, l‐NAME potentiated the psychopharmacological effects of morin in the open field and forced swim tests but reduced its memory promoting effect. Meanwhile, morin supplementation reversed the effects of l‐arginine on l‐NAME‐treated mice in all behavioral models. The results of this study suggest that l‐arginine‐nitric oxide pathway might play a role in the modulation of the antidepressant and memory promoting effects of morin in mice.

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Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

Mokhtari

2022

Phytotherapy Research

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Major depressive disorder (MDD) is a life‐threatening disease that presents several characteristics. The pathogenesis of depression still remains poorly understood. Moreover, the mechanistic interactions of natural components in treating depression to target autophagy and neuroinflammation are yet to be evaluated. This study overviewed the effects of plant‐derived natural components in regulating critical pathways, particularly neuroinflammation and autophagy, associated with depression. A list of natural components, including luteolin, apigenin, hyperforin, resveratrol, salvianolic acid b, isoliquiritin, nobiletin, andrographolide, and oridonin, have been investigated. All peer‐reviewed journal articles were searched by Scopus, MEDLINE, PubMed, Web of Science, and Google Scholar using the appropriated keywords, including depression, neuroinflammation, autophagy, plant, natural components, etc. The neuroinflammation and autophagy dysfunction are critically associated with the pathophysiology of depression. Natural components with higher efficiency and lower complications can be used for targeting neuroinflammation and autophagy. These components with different doses showed the beneficial antidepressant properties in rodents. These can modulate autophagy markers, mainly AMPK, LC3II/LC3I ratio, Beclin‐1. Moreover, they can regulate the NLRP3 inflammasome, resulting in the suppression of proinflammatory cytokines (e.g., IL‐1β and IL‐18). Future in vitro and in vivo studies are required to develop novel therapeutic approaches based on plant‐derived active components to treat MDD.

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Implication of NMDA-NO pathway in the antidepressant-like effect of ellagic acid in male mice

Cited by 32 publications

References 58 publications

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

Trigonelline through the Attenuation of Oxidative Stress Exerts Antidepressant- and Anxiolytic-Like Effects in a Mouse Model of Maternal Separation Stress

Involvement of l‐arginine‐nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice

Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents

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