Implication of sperm chromosomal abnormalities in recurrent abortion and multiple implantation failure

Abstract

Currently, some infertility treatment centres provide sperm karyotype analysis, although the impact of sperm chromosomal abnormalities on fertility is not yet fully understood. Several studies using fluorescence in-situ hybridization (FISH) to analyse sperm chromosomal constitution discovered that the incidence of aneuploidy is increased in individuals with a history of repeated abortion or implantation failure and is even higher in cases of oligoasthenoteratozoospermia (OAT), abnormal somatic karyotype or in spermatozoa retrieved directly from the testis or epididymis, showing that the application of FISH in these cases may be of some benefit for improving the reproductive outcome. This article presents the results of clinical trials of FISH analysis on spermatozoa, the medical indications for performing this examination, its results in infertile patients and the advantages when performing genetic counselling prior to treatment. Also discussed is the possibility of applying the latest techniques of genetic analysis in these cases and the potential benefits for improving the prognosis of male infertility.

Sperm aneuploidy and recurrent pregnancy loss: A systematic review and meta-analysis

“…Additionally, the included trials showed high quality and precision. Other studies (Caseiro et al, 2015;Giorlandino et al, 1998;Lou et al, 2013;Rosenbusch et al, 1991) were mostly consistent with our current findings. These studies showed that the incidence of aneuploidy was increased in individuals with a history of repeated abortion.…”

Long non‑coding RNA H19 regulates Bcl‑2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion

“…SA is the most frequently occurring pregnancy disorder and is a serious threat to women's health (23). SA has been reported to be associated with several risk factors, including endocrine disorders, anatomic deformation, immunodeficiency and chromosomal abnormalities (24)(25)(26)(27). However, other risk factors and underlying molecular mechanisms of SA still need further investigation.…”

Sperm telomere length in motile sperm selection techniques: A qFISH approach

“…In reproduction, telomeres may play an important role in chromosome pairing during meiosis (Bekaert, Derradji, & Baatout, ; de La Roche Saint‐André, ). Alterations at this level could cause segregation problems and a higher rate of sperm aneuploidy, apoptosis and lower sperm count (Perrin et al., ; Templado, Donate, Giraldo, Bosch, & Estop, ), which are features directly associated with infertility, miscarriages and implantation failure (Caseiro et al., ; Neusser et al., ).…”