Implication of the Central Nucleus of the Amygdala in Cardiovascular Regulation and Limiting Maximum Exercise Performance During High-intensity Exercise in Rats

Tsukioka, Kei; Yamanaka, Koji; Waki, Hidefumi

doi:10.1016/j.neuroscience.2022.06.005

Cited by 4 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our retrograde findings also revealed a projection to the CUN from the medial part of the central amygdalar nucleus, a projection also reported in previous anterograde tract-tracing studies. 32,33 The central amygdalar nucleus is known to participate in conditioned fear responses to aversive stimuli, 34 prey hunting, 35 and diverse autonomic responses, including cardiovascular 36,37 and gastrointestinal control. 38,39 Thus, the central amygdalar nucleus is in a position to interact with the CUN and possibly influence its role in the defensive behavior and autonomic functions, particularly those related to the control of sympathetic vasomotor activity.…”

Section: Neuronal Connections Of the Cunmentioning

confidence: 99%

Anatomical and functional study of the cuneiform nucleus: A critical site to organize innate defensive behaviors

Bindi

Guimarães

Oliveira

et al. 2023

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The cuneiform nucleus (CUN) is a midbrain structure located lateral to the caudal part of the periaqueductal gray. In the present investigation, we first performed a systematic analysis of the afferent and efferent projections of the CUN using FluoroGold and Phaseolus vulgaris leucoagglutinin as retrograde and anterograde neuronal tracers, respectively. Next, we examined the behavioral responses to optogenetic activation of the CUN and evaluated the impact of pharmacological inactivation of the CUN in both innate and contextual fear responses to a predatory threat (i.e., a live cat). The present hodologic evidence indicates that the CUN might be viewed as a caudal component of the periaqueductal gray. The CUN has strong bidirectional links with the dorsolateral periaqueductal gray (PAGdl). Our hodological findings revealed that the CUN and PAGdl share a similar source of inputs involved in integrating information related to life-threatening events and that the CUN provides particularly strong projections to brain sites influencing antipredatory defensive behaviors. Our functional studies revealed that the CUN mediates innate freezing and flight antipredatory responses but does not seem to influence the acquisition and expression of learned fear responses.

show abstract

Section: Neuronal Connections Of the Cunmentioning

confidence: 99%

Anatomical and functional study of the cuneiform nucleus: A critical site to organize innate defensive behaviors

Bindi

Guimarães

Oliveira

et al. 2023

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…1A; 55 cm × 10 cm, width measured from the shock grid; MK-680, Muromachi Kikai, Tokyo, Japan). To begin with, as in the previous study 9) , the rats were familiarized with the treadmill using a habitual protocol lasting 60 min per day for three days. They were made to start running at an initial speed of 10 m/min, and the speed was increased by 2 m/min every 10 min up to a maximum of 20 m/min (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…The amygdala, one of the most wellknown brain regions that process emotions, is involved in the autonomic responses 7) . Our previous studies have demonstrated that electrical and/or chemical stimulation of the central nucleus of the amygdala (CeA) increases blood pressure and causes vascular resistance 8,9) . We have also shown that HIE causes CeA activation 10) and that CeA lesions are associated with prolonged maximal treadmill running time and cardiovascular regulation during HIE 9) .…”

Section: Introductionmentioning

confidence: 99%

“…Our previous studies have demonstrated that electrical and/or chemical stimulation of the central nucleus of the amygdala (CeA) increases blood pressure and causes vascular resistance 8,9) . We have also shown that HIE causes CeA activation 10) and that CeA lesions are associated with prolonged maximal treadmill running time and cardiovascular regulation during HIE 9) . Thus, the CeA may affect cardiovascular regulation and limit athletic performance by disrupting circulatory dynamics (e.g., accumulation of metabolites due to increased muscle vascular resistance) during HIE.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the CeA may affect cardiovascular regulation and limit athletic performance by disrupting circulatory dynamics (e.g., accumulation of metabolites due to increased muscle vascular resistance) during HIE. The CeA has anatomical connections with the PVH and NTS, suggesting that these three brain regions may cooperate to regulate cardiovascular responses during HIE 9) . However, it remains unclear whether and how the CeA-PVH-NTS regions interact in a coordinated manner during HIE.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional connectivity in central nucleus of amygdala, paraventricular hypothalamus, and nucleus tractus solitarii circuits during high-intensity endurance treadmill exercise in rats

Ezure

Yamanaka

et al. 2023

JPFSM

Self Cite

View full text Add to dashboard Cite

High-intensity endurance exercise (HIE) induces negative emotions alongside fatigue, suffering, and changes in cardiovascular responses, and these regulations could be important for athletic performance. Previous studies have reported that limbic and brain stem regions, including the central nucleus of the amygdala (CeA), the paraventricular nucleus of the hypothalamus (PVH), and the nucleus tractus solitarii (NTS), play important roles in emotional response and autonomic cardiovascular regulation. However, how these brain regions interact during HIE remains unclear. In this study, Wistar rats were subjected to 90-min treadmill running sessions at different endurance exercise intensities (sedentary, low-intensity, and highintensity: 0, 20, and 34 m/min, respectively; n = 9 per group). After exercise, brain tissues were extracted and examined for c-Fos immediate early gene expression in brain regions such as the CeA, PVH, and NTS at each exercise intensity. The c-Fos-positive cells were counted, and then a partial correlation analysis was performed to examine the functional connectivity during exercise. As a result, the numbers of c-Fos-positive cells in the CeA, PVH, and NTS increased in an exercise intensity-dependent manner. Furthermore, partial correlation analyses of c-Fos-positive cells between CeA and NTS (CeA-NTS), PVH and NTS (PVH-NTS), and CeA and PVH (CeA-PVH) exhibited significant correlation coefficients during HIE but not during sedentary and low-intensity endurance exercises. Thus, these results suggest that functional connectivity between CeA-PVH, PVH-NTS, and CeA-NTS may be enhanced during HIE. This enhanced functional connectivity may also be involved in emotional and cardiovascular regulation during exercise.

show abstract

Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice

Wang,

Yue,

Shi

et al. 2024

Neurosci. Bull.

View full text Add to dashboard Cite

Implication of the Central Nucleus of the Amygdala in Cardiovascular Regulation and Limiting Maximum Exercise Performance During High-intensity Exercise in Rats

Cited by 4 publications

References 43 publications

Anatomical and functional study of the cuneiform nucleus: A critical site to organize innate defensive behaviors

Anatomical and functional study of the cuneiform nucleus: A critical site to organize innate defensive behaviors

Functional connectivity in central nucleus of amygdala, paraventricular hypothalamus, and nucleus tractus solitarii circuits during high-intensity endurance treadmill exercise in rats

Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice

Contact Info

Product

Resources

About