Implications and Practical Applications of the Chemical Speciation of Iodine in the Biological Context

Espino-Vázquez, A.; Rojas-Castro, Flor C.; Fajardo-Yamamoto, Liria Mitzuko

doi:10.3390/futurepharmacol2040026

Cited by 5 publications

(3 citation statements)

References 253 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The iodide then returns to the blood compartment. This active cycling of iodide could be related to the antioxidant properties of iodine in its ionic form (I-) which would accumulate to protect cells against oxidative stress 64, 65 . Conversely, reactive forms of iodine (e.g., I2) or other oxidized anions carried by NIS, such as thiocyanate 66 and nitrate 67 , could have a bactericidal effect on the food bolus.…”

Section: Discussionmentioning

confidence: 99%

New insights into iodide metabolism based on preclinical models: impact on radiotherapy efficacy and protection against radioactive iodine exposure

Guglielmi,

D’Andréa,

Graslin

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: The main basic aspects of the regulation of thyroid metabolism by iodine has known, but given the complexity of the mechanisms involved, further analyzes in living animals are still required. Here, we provided new insights into iodine physiology but also into the optimization of radiotherapy with iodine, as well as effective countermeasures in the case of an exposure to radioactive iodine. Methods: We performed Single Photon Emission Computed Tomography (SPECT) coupled to an X-ray scanner to record radiotracers in living mice and rats. Our imaging system is like that routinely used in nuclear medicine but was specifically designed for studies with small animals. Different modalities of administration of iodine or its radioactive analogues combined with a low or high iodine diet have been studied in pregnant, lactating and control animals. To optimize countermeasures against acute or chronic iodine exposure, the protective effects of potassium iodide (KI) administration protocols were analyzed. Perchlorate was administered to study the iodine metabolism in the kidney and stomach. Results: Our results showed how the various organs capable of iodine uptake adapt to an iodine-deficient diet. Indeed, the uptake capacity of the thyroid gland, but also that of the salivary glands was significantly increased on a low iodine diet. In contrast, the iodine uptake capacity of the thyroid and lactating mammary glands was reduced on an iodide-rich diet. Our results also showed the physiological role of the kidneys in controlling excess circulating iodide. In addition, they revealed an active iodine cycle in the stomach. We also investigated the protective effects of daily KI administration during radioactive iodine exposure and found that the overall protection was better in rats (85%) than in mice (65%). We also included pregnant females and newborns in this series of experiments, and we revealed the existence of specific mechanisms for the inhibition of the fetal thyroid by circulating iodine. Indeed, an iodine-rich diet or repeated daily administration of KI led to a strong inhibition of the iodine uptake capacity of the fetal thyroid. Conclusions: Our study contributes to a better understanding of iodine metabolism and its regulation in the thyroid and in non-thyroidal organs in adult, fetal and newborn animals. Extrapolated to humans, our results not only provide better understanding of iodide withdrawal as a clinical preparatory measure for patients with differentiated thyroid cancer, but also help to optimize countermeasures in the case of an exposure to radioactive iodine.

show abstract

Section: Discussionmentioning

confidence: 99%

New insights into iodide metabolism based on preclinical models: impact on radiotherapy efficacy and protection against radioactive iodine exposure

Guglielmi,

D’Andréa,

Graslin

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The overall reaction of this catalytic event is two molecules of hydrogen peroxide decomposing into two molecules of water plus oxygen. 11 Given that the process is initiated following the dissociation of the salt, the sodium counterion likely has little effect on the actual mechanism of action. The choice of counterion does, however, affect other factors including the solubility and molecular weight of the compound.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…The overall reaction of this catalytic event is two molecules of hydrogen peroxide decomposing into two molecules of water plus oxygen. 11…”

Section: Mechanism Of Actionmentioning

confidence: 99%

FDY-5301: An Innovative Approach to The Treatment of Revascularization Coronary Injury

Williams

Frishman

2023

Cardiology in Review

View full text Add to dashboard Cite

After experiencing an acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) is a preferred method of restoring blood flow to the heart. While this reperfusion has long-term benefits, it can result in reperfusion injury in the short term, which involves the formation of reactive oxygen species (ROS) and neutrophil recruitment. FDY-5301 is a sodium iodide-based drug that acts as a catalyst in the conversion of hydrogen peroxide to water and oxygen. FDY-5301 is designed to be administered as an intravenous bolus following a STEMI, before reperfusion with PCI, to reduce the damage associated with reperfusion injury. Clinical trials have shown FDY-5301 administration to be safe, feasible, and fast-acting in its ability to increase plasma iodide concentration, and the results are favorable in demonstrating potential efficacy. FDY-5301 shows potential in its use to reduce the effects of reperfusion injury, and ongoing Phase 3 trials will allow for continued evaluation of its performance.

show abstract

Alginate as a Sustainable and Biodegradable Material for Medical and Environmental Applications—The Case Studies

Wawszczak,

Kocki,

Kołodyńska

2024

J Biomed Mater Res

View full text Add to dashboard Cite

Alginates are salts of alginic acid derived mainly from sea algae of the genus brown algae. They are also synthesized by some bacteria. They belong to negatively charged polysaccharides exhibiting some rheological properties. High plasticity and the ability to modify the structure are the reasons for their application in numerous industries. Moreover, when in contact with the living tissue, they do not trigger an immune response, and for this reason they are the most often tested materials for medical applications. The paper discusses the latest applications, including 3D bioprinting, drug delivery systems, and sorptive properties. Recognizing alginates as biomaterials, it emphasizes the necessity for precise processing and modification to industrialize them for specific uses. This review aims to provide a thorough understanding of the advancements in alginate research, underscoring their potential for innovative applications.

show abstract

Implications and Practical Applications of the Chemical Speciation of Iodine in the Biological Context

Cited by 5 publications

References 253 publications

New insights into iodide metabolism based on preclinical models: impact on radiotherapy efficacy and protection against radioactive iodine exposure

New insights into iodide metabolism based on preclinical models: impact on radiotherapy efficacy and protection against radioactive iodine exposure

FDY-5301: An Innovative Approach to The Treatment of Revascularization Coronary Injury

Alginate as a Sustainable and Biodegradable Material for Medical and Environmental Applications—The Case Studies

Contact Info

Product

Resources

About