2008
DOI: 10.1098/rstb.2007.2257
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Implications of activity-dependent neurotransmitter–receptor matching

Abstract: Electrical activity has numerous roles in early neuronal development. Calcium transients generated at low frequencies regulate neural induction and neuronal proliferation, migration and differentiation. Recent work demonstrates that these signals participate in specification of the transmitters expressed in different classes of neurons. Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and … Show more

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Cited by 30 publications
(21 citation statements)
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“…For ChAT, trophic support could increase as the CST strengthens its connections during development ). The raised CST drive increases ChAT expression, since neurotransmitter phenotype can be activity dependent (Spitzer and Borodinsky, 2008). We further propose that the ChAT-CB ratio is an index of the balance between excitation (ChAT) and inhibition (CB).…”
Section: Model For Developmental Changes In Chat and Cbmentioning
confidence: 83%
“…For ChAT, trophic support could increase as the CST strengthens its connections during development ). The raised CST drive increases ChAT expression, since neurotransmitter phenotype can be activity dependent (Spitzer and Borodinsky, 2008). We further propose that the ChAT-CB ratio is an index of the balance between excitation (ChAT) and inhibition (CB).…”
Section: Model For Developmental Changes In Chat and Cbmentioning
confidence: 83%
“…Therefore, neuronal activity ensures matching of transmitters and receptors in the assembly of functional synapses. Correct sorting of neurotransmitter and postsynaptic receptors is not required initially, but nonfunctional synapses are replaced during neuronal maturation (2,32).…”
Section: Discussionmentioning
confidence: 99%
“…Electrical activity exerts a key role in controlling the specificity of neurotransmitter/receptor matching, both during the developmental period and in the mature brain (1,2). Vertebrate skeletal muscle expresses five classes of neurotransmitter receptors at early developmental stages, four of which are eliminated during the achievement of the mature cholinergic phenotype.…”
mentioning
confidence: 99%
“…Meaningful information transfer at synapses ultimately requires the correct matching of postsynaptic receptors with the identity of the neurotransmitter (Lardi-Studler and Fritschy, 2007; Spitzer and Borodinsky, 2008). This process is perhaps the best understood at the neuromuscular junction where the expression of postsynaptic acetylcholine receptors is modulated by changes in electrical activity as the synapse develops (Borodinsky and Spitzer, 2007).…”
Section: Introductionmentioning
confidence: 99%