Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

Abstract

Introduction: Advanced oxidation protein products (AOPP) are considered as markers of oxidative stress and inflammation, and highly predictive of atherosclerosis. Vitamin E (Vit-E) is a powerful antioxidant, but no consensus on its effectiveness at the level of AOPP or the process of atherosclerosis has been made. Hence this was the aim of the present study. Material and methods: A longitudinal study was conducted on 205 patients with chronic kidney disease (CKD) and 40 controls. The correlations between AOPP and glomerular filtration rate (GFR) and different biological markers were analyzed. Supra-aortic trunk echo-Doppler was conducted to assess the correlation of AOPP with intima-media thickness. The effects of Vit-E treatment on AOPP levels and atherosclerosis progression were also investigated. Results: AOPP levels increased in parallel to the alteration of renal functions in CKD patients, compared to the control group (p < 0.05). The mean value of AOPP increased concomitantly with the intima-media thickness (p < 0.05). Furthermore, AOPP mean value was higher in patients with atherosclerotic plaques (p < 0.05) compared to those without plaques. Vit-E treatment stabilized the levels of AOPP but had no effect on the atherosclerotic progression. Conclusions: AOPP were proved to be effective markers of oxidative stress and their high levels help to predict the progression of atherosclerosis. As a powerful antioxidant, Vit-E stabilized the AOPP levels.

Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction

“…Advanced oxidation protein products (AOPP) are a marker of oxidative stress first detected in the plasma of chronic uremic patients [3]. AOPP originates from reactions between free radicals, chlorinated oxidants, and plasma proteins [6], mainly albumin [7]. They can either escalate the OS or reactive oxygen species (ROS) generation [7][8][9].…”

“…AOPP originates from reactions between free radicals, chlorinated oxidants, and plasma proteins [6], mainly albumin [7]. They can either escalate the OS or reactive oxygen species (ROS) generation [7][8][9]. AOPP is also associated with coronary artery disease (CAD) [10], atherosclerosis [11], and comorbidities, such as diabetes mellitus (DM), hypertension, metabolic syndrome [12], and lipid disorders (hypercholesterolemia and hypertriglyceridemia) [13].…”