Implications of Antidepressants Use in Breast Cancer: A Brief Review

Strazzanti, Angela; Martorana, Federica; Intagliata, Eva; Lanzafame, Katia; Pavone, Giuliana; Sergi, Mauro; Gangi, Santi; Manzella, Livia; Burzotta, Francesco; Trovato, Claudio

doi:10.21614/sgo-25-5-229

Cited by 3 publications

(1 citation statement)

References 24 publications

(29 reference statements)

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“…The interaction between drugs used for BC treatment and those for HIV management complicates the therapeutic approach, potentially contributing to the observed higher mortality rates in BC patients with HIV. This phenomenon is similar to interactions observed with other classes of drugs [ 72 ]. In this contest, a lack of guidelines and education between healthcare providers often results in the substandard cancer care offered to HIV+ve BC patients [ 73 , 74 ].…”

Section: Clinical Outcomes Of Hiv+ve Breast Cancer Patientssupporting

confidence: 85%

Navigating the Nexus: HIV and Breast Cancer—A Critical Review

Marino,

Pavone,

Martorana

et al. 2024

IJMS

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Despite significant advances in the management of antiretroviral therapy (ART), leading to improved life expectancy for people living with HIV (PLWH), the incidence of non-AIDS-defining cancers, including breast cancer, has emerged as a critical concern. This review synthesizes current evidence on the epidemiology of breast cancer among HIV-infected individuals, highlighting the potential for an altered risk profile, earlier onset, and more advanced disease at diagnosis. It delves into the molecular considerations underpinning the relationship between HIV and breast cancer, including the role of immunosuppression, chronic inflammation, and gene expression alterations. Additionally, it examines the complexities of managing breast cancer in the context of HIV, particularly the challenges posed by ART and anticancer agents’ cross-toxicities and drug–drug interactions. The review also addresses survival disparities, underscoring the need for improved cancer care in this population. By identifying gaps in knowledge and areas requiring further research, this review aims to illuminate the complexities of HIV-associated breast cancer, fostering a deeper understanding of its epidemiology, molecular basis, and clinical management challenges, thereby contributing to better outcomes for individuals at the intersection of these two conditions. This narrative review systematically explores the intersection of HIV infection and breast cancer, focusing on the impact of HIV on breast cancer risk, outcomes, and treatment challenges.

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Section: Clinical Outcomes Of Hiv+ve Breast Cancer Patientssupporting

confidence: 85%

Navigating the Nexus: HIV and Breast Cancer—A Critical Review

Marino,

Pavone,

Martorana

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome

Cucciniello,

Garufi,

Di Rienzo

et al. 2023

Cancer Treatment Reviews

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Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review

Pavone,

Marino,

Fisicaro

et al. 2024

IJMS

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Cervical cancer (CC) remains a prevalent malignancy and a significant global public health concern, primarily driven by persistent human papillomavirus (HPV) infections. The infectious nature of HPV underscores the preventability of CC through vaccination and screening programs. In addition to HPV, factors such as age, parity, smoking, hormonal contraceptives, and HIV co-infection elevate the risk of CC. HIV-associated immunodeficiency exacerbates susceptibility to infections and cancers, making CC a defining condition for acquired immune deficiency syndrome (AIDS) and one of the most commonly diagnosed cancers among women living with HIV (WLWH). These women face higher risks of HPV exposure due to sexual behavior and often encounter economic, social, and psychological barriers to screening. HIV and HPV co-infection can potentially accelerate CC carcinogenesis, with WLWH typically being diagnosed with CC earlier than their HIV-negative counterparts. Antiretroviral therapy (ART), which reduces AIDS-related mortality, also lowers the risk of invasive CC. The interaction between HIV and HPV is intricate and bidirectional. This summary reviews current evidence on HPV infection and CC in WLWH, highlighting the connections across pathogenesis, prevention, diagnosis, and treatment.

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Implications of Antidepressants Use in Breast Cancer: A Brief Review

Cited by 3 publications

References 24 publications

Navigating the Nexus: HIV and Breast Cancer—A Critical Review

Navigating the Nexus: HIV and Breast Cancer—A Critical Review

Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome

Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review

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