Implications of Antioxidant Systems in Inflammatory Bowel Disease

Guan, Guijian; Lan, Shan

doi:10.1155/2018/1290179

Cited by 106 publications

(73 citation statements)

References 53 publications

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“…In particular, intestinal epithelial cells (IECs) can sense and respond to microbial stimuli to reiforce the barrier function and to participate in the coordination of an appropriate immune response. 7 Thus, the control of the inflammation and the oxidative stress has a primary role in the IBDs treatment. 3 The main factors involved in the inflammatory cascade during IBDs are cytokines (eg, tumor necrosis factor-α, TNF-α; interferon-γ, IFN-γ; interleukin-6, IL-6), which are also linked to nuclear factor-κB (NF-κB) activation, chemokines, adhesion molecules, and reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

et al. 2019

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Inflammatory bowel diseases (IBDs) are characterized by an inflammatory and oxidative stress condition in the intestinal tissue. In this study, we evaluated the effect of plumericin, one of the main bioactive components of Himatanthus sucuuba (Woodson) bark, on intestinal inflammation and oxidative stress, both in vitro and in vivo. The effect of plumericin (0.5‐2 µM) in vitro was evaluated in rat intestinal epithelial cells (IEC‐6) treated with lipopolysaccharides from E. coli (10 μg/mL) plus interferon‐γ (10 U/mL). Moreover, a 2,4,6‐dinitrobenzene sulfonic acid (DNBS)‐induced colitis model was used to evaluate the anti‐inflammatory and antioxidant activity of plumericin (3 mg/kg) in vivo. The results showed that plumericin significantly reduces intestinal inflammatory factors such as tumor necrosis factor‐α, cyclooxygenase‐2 and inducible nitric oxide synthase expression, and nitrotyrosine formation. Plumericin also inhibited nuclear factor‐κB translocation, reactive oxygen species (ROS) release, and inflammasome activation. Moreover, plumericin activated the nuclear factor erythroid‐derived 2 pathway in IEC‐6. Using the DNBS‐induced colitis model, a significant reduction in the weight loss and in the development of the macroscopic and histologic signs of colon injury, together with a reduced inflammatory and oxidative stress state, were observed in plumericin‐treated mice. These results indicate that plumericin exerts a strong anti‐inflammatory and antioxidant activity. Thus, it might be a candidate for the development of a new pharmacologic approach for IBDs treatment.

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Section: Introductionmentioning

confidence: 99%

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

et al. 2019

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“…In this study, we did not evaluate oxidative stress nor expression of antioxidant enzymes. However, as increasing evidence suggested that DSS creates oxidative stress in mice [ 57 ] and induces pro-inflammatory cytokines [ 58 ]; thus, antioxidants are suggested to be used to treat IBD [ 59 ]. Moreover, a number of studies have reported that antioxidants alter cytokine production [ 60 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Properties and Gut Microbiota Modulation of Porphyra tenera Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice

Kim

Choi

et al. 2020

Antioxidants

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Porphyra tenera (PT) is a functional seaweed food that has been reported for health benefits such as antioxidant, immunostimulant, anti-inflammation, and hepatoprotective effects. In this study, we investigated the effect of PT extracts on gut microbiota modulation in colitis-induced mice. The mice experiment was designed as three groups including normal mice (CTL), dextran sodium sulfate (DSS)-fed mice, and DSS plus PT extracts-fed mice (PTE). DSS was administrated through drinking water containing DSS for 1 week, and the PT extract was ingested into the gastrointestinal tract in mice. PT extract ameliorated the decreased body weight and colon length and improved disease activity index and pro-inflammatory cytokine expression. In addition, PT extract significantly shifted the gut microbiota of mice. DSS treatment significantly increased the portion of harmful bacteria (i.e., Helicobacter, Mucipirillum, and Parasutterella) and decreased the butyrate producing bacteria (i.e., Acetatifactor, Alistipes, Oscillibacter, and Clostridium_XIVb). PT extract increased the abundance of genera Clostridium_XIVb and also enriched some of predicted metabolic activities such as glyoxylate cycle, ethylmalonyl-CoA pathway, nitrate reduction, creatinine degradation, and glycine betaine metabolism. These results suggest that PT extract may ameliorate the DSS-induced colitis inflammation through regulating the compositions and functions of gut microbiota in mice.

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“…During experimental colitis, the oxidants play a critical role in the inflammatory reaction by increasing the number of neutrophils and macrophages that induce a self-sustaining loop (Kurutas, Cetinkaya, Bulbuloglu, & Kantarceken, 2005;van der Veen, de Winther, & Heeringa, 2009). Endogenous antioxidants degrade highly reactive oxygen species (ROS), thus become important targets for IBD treatment (Guan & Lan, 2018). Herein, we detected lipid peroxide (i.e.…”

Section: Discussionmentioning

confidence: 93%

Protective effects of myristicin against ulcerative colitis induced by acetic acid in male mice

Badr

Amalki

Alfwuaires

et al. 2020

Food and Agricultural Immunology

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The present investigation aims to evaluate the prophylactic effects and mechanisms of Myr on experimental colitis model induced by acetic acid (AA) in mice. The obtained results showed that Myr treatment prior to induction of colitis significantly modulated the colonic oxidative stress by increasing the antioxidant enzymatic activities of catalse, superoxide dismutase, glutathione peroxidase and glutathione reductase, as well as by lowering the levels of lipid peroxidation. The treatment also significantly decreased the colonic tissue levels of inflammatory markers, including myeloperoxidase activity, tumour necrosis factor-alpha, interleukin-1 and interleukin-17. Besides, Myr significantly inhibited nuclear factor-kappa B (NF-κB) levels in AA-induced ulcerative colitis tissues. In the histological evaluation, the tissue damage scores in the mice colon were significantly suppressed with the administration of Myr + AA. Taken together, our findings suggested that Myr exerts marked protective effect against colonic inflammation through regulating antioxidative responses, NF-κB and subsequent pro-inflammatory cytokines production.

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Implications of Antioxidant Systems in Inflammatory Bowel Disease

Cited by 106 publications

References 53 publications

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo

Anti-Inflammatory Properties and Gut Microbiota Modulation of Porphyra tenera Extracts in Dextran Sodium Sulfate-Induced Colitis in Mice

Protective effects of myristicin against ulcerative colitis induced by acetic acid in male mice

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