Implications of COVID-19 infections in sickle cell disease

John, Nitin Ashok; John, Jyoti

doi:10.11604/pamj.2020.36.81.23776

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…The decreased effect of serum cytokines is one of the side effects of COVID-19 in some of them (15). Mortality from COVID disease is higher in patients with sickle cell disease and chronic respiratory or cardiovascular disease and hypertension than in patients with sickle cell disease alone (16). Examination of blood cells in patients with COVID-19 and sickle cell anemia revealed that all blood cells were stable, and only white blood cells were reduced.…”

Section: Resultsmentioning

confidence: 99%

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Sickle Cell Disease and COVID-19

Moradi

2020

J Arch Mil Med

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Context: The COVID-19 pandemic emerged in China and spread to the majority of countries worldwide, causing numerous health problems and restrictions on the people’s lifestyles. The complications of this disease can be much more severe in patients who have a weakened immune system or a chronic disease. Sickle cell disease is a genetic disorder in which the immune system is impaired. Exposure to COVID-19 will have severe consequences in the sickle cell disease patients. In this study aimed to investigate the relationship between this disease with the COVID-19 pandemic. Evidence Acquisition: Embase, Scopus, Pub Med databases were reviewed. Keywords were combined as (“COVID19” OR “Coronavirus” AND “Anemia sickle Cell” OR “Sickle cell disease”). The results of related articles were used. Results: At the time of the COVID-19 pandemic, chronic patients and those with weakened immune systems need to be more socially inclined to be less exposed to the COVID-19 virus. Conclusions: When producing the COVID vaccine, high-risk groups such as sickle cell anemia patients should be given priority.

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Section: Resultsmentioning

confidence: 99%

“…Complications of sickle cell disease are permanent and temporary defects of the immune system, and the main symptom is fever. Every patient with this symptom should also be screened for COVID-19, regardless of whether they are exposed to the Coronavirus (16).…”

Section: Resultsmentioning

confidence: 99%

Sickle Cell Disease and COVID-19

Moradi

2020

J Arch Mil Med

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“…In some cases, even individuals with sickle cell trait are considered to be at risk ( 40 , 110 , 112 , 119 ). The immunosuppressive state, increased risk of sepsis, endothelial dysfunction, and cardiovascular impairment are some of the characteristics of sickle cell disease that may explain these outcomes ( 2 , 51 , 54 , 61 , 63 , 66 , 68 ). The fact that COVID-19 acts as a trigger for the occurrence of sickle cell complications, which are events that are associated with high mortality, may also contribute to this scenario, as will be discussed in the next section.…”

Section: Discussionmentioning

confidence: 99%

Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

et al. 2023

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Sickle cell disease is the most common hemoglobinopathy among humans. As the condition promotes susceptibility to infections, chronic inflammation, and hypercoagulability disorders, several international agencies have included individuals with this disease in the COVID-19 risk group for severe outcomes. However, available information about the subject is not properly systematized yet. This review aimed to understand and summarize the scientific knowledge about the impact of SARS-CoV-2 infection in patients with sickle cell disease. Searches were performed in the Medline, PubMed, and Virtual Health Library databases based on descriptors chosen according to the Medical Subject Headings. We analyzed studies published between 2020 and October 2022, developed with qualitative, quantitative, or mixed methodology, and written in English, Spanish, or Portuguese. The search resulted in 90 articles organized into six categories. There is disagreement in the literature about how different aspects related to sickle cell disease, such as chronic inflammation status, hypercoagulability, hemolytic anemia, use of hydroxyurea, and access to medical care interference with the clinical course of COVID-19. These topics deserve further investigation. It is evident, however, that the infection may manifest in an atypical way and act as a trigger for the development of sickle cell-specific complications, such as acute chest syndrome and vaso-occlusive crises, conditions that are associated with great morbidity and mortality. Therefore, healthcare professionals must be aware of the different forms of presentation of COVID-19 among these individuals. Specific guidelines and therapeutic protocols, as well as public policies for sickle cell individuals, must be considered.Systematic review registrationThis review (https://doi.org/10.17605/OSF.IO/NH4AS) and the review protocol (https://osf.io/3y649/) are registered in the Open Science Framework platform.

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“…In addition, patients with pre-existing medical conditions have a higher risk, both for contracting the virus and for developing severe complications from the infection. This is particularly true for patients living with NCDs such as Hypertension, Diabetes, heart disease, cancer and sickle cell disorder (SCD), who often have a compromised respiratory system (John and John 2020).…”

Section: Background Of Studymentioning

confidence: 99%

“…Nigeria has the largest burden of SCD globally with an estimated 150,000 babies born annually with the condition (Akodu et al, 2013). It is therefore a major concern as patients living with SCD are immunocompromised and at risk of suffering from chronic or acute complications due to COVID which may require urgent hospitalisation and intensive care (John and John 2020).…”

Section: Background Of Studymentioning

confidence: 99%

Impact of COVID-19 on the quality of life (QoL) of patients living with Sickle Cell Disorder (SCD) in Lagos, Nigeria

Akinsete

Ajuwon²,

Micheal³

et al. 2021

Preprint

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The study aimed to assess the impact of the COVID-19 pandemic on Quality of Life (QoL) in persons living with Sickle Cell Disorder (SCD) in Lagos, Nigeria and to determine how they coped during the pandemic, particularly during the period of total lockdown with the additional SHIELDING measures to which they had to adhere. Data was collected using a standardized protocol PedsQL, Sickle Cell Disease Module version 3, designed for youth within the ages of 13 to 18 years and 19 to 35 years and their parents and guardian if underage. The survey captured data on patients pain impact, hurts, management, treatments, communication with their caregivers and their guardians perception. The survey was performed online, or face to face and telephone interview if online was not possible. Contacts of patients and parents were obtained from the database of Sickle Cell Foundation Nigeria. A total of 105 (80 patients and 25 parents) participants responded to the survey. The age distribution of respondents was highest at 56 percent in the age bracket of 13 to 18 years old. Pain crisis were very common amongst patients. The survey revealed that the type of treatment or care received at these times determined whether or not the patients visited the hospital when they had pain crises. In addition, as patients reports an increase in ill treatment they experienced in the hands of health care givers, so did the fear of accessing treatment during the COVID pandemic. It was observed that the frequency of pain crises experienced by SCD patients was proportional to the patients quality of life (the higher the frequency of pains, the worse the QoL). As a follow-up, a more detailed study would be required, as this study was limited in the capturing of the demographics, sex and number of participants; Considering the number of persons living with SCD that visit the Sickle Cell Foundation Nigeria, (approx. 3,000 patients), the number of responses in this study was low (105). It is believed that a higher number of responses would have given more information about the Sickle Cell burden and the QoL of persons living with SCD in Lagos during the COVID-19 pandemic. Lagos was the epicentre of the COVID-19 pandemic in Nigeria.

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Implications of COVID-19 infections in sickle cell disease

Cited by 5 publications

References 8 publications

Sickle Cell Disease and COVID-19

Sickle Cell Disease and COVID-19

Impact of the SARS-CoV-2 infection in individuals with sickle cell disease: an integrative review

Impact of COVID-19 on the quality of life (QoL) of patients living with Sickle Cell Disorder (SCD) in Lagos, Nigeria

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